No influence of atopic diseases on antibody titres following tetanus,diphtheria and hepatitis B immunisation among adults |
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Authors: | N Friedrich A Kramer R Mentel L Gürtler U John H Völzke |
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Institution: | (1) Institute of Community Medicine, Ernst Moritz Arndt University of Greifswald, Walther-Rathenau-Str. 48, 17487 Greifswald, Germany;(2) Institute of Epidemiology and Social Medicine, Ernst Moritz Arndt University of Greifswald, Walther-Rathenau-Str. 48, 17487 Greifswald, Germany;(3) Institute of Hygiene and Environmental Medicine, Ernst Moritz Arndt University of Greifswald, Walter-Rathenau-Str. 49A, 17487 Greifswald, Germany;(4) Institute of Microbiology, Ernst Moritz Arndt University of Greifswald, Martin-Luther-Str. 6, 17487 Greifswald, Germany |
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Abstract: | Several studies have reported associations between reduced humoral immune response to vaccine antigens and diseases with modified
reactions of the immune system. We have investigated the influence of atopic diseases on specific IgG levels to tetanus, diphtheria
and hepatitis B (HB), following immunisation, in a general adult population. From the Study of Health in Pomerania, a total
number of 3,920 subjects aged 20 to 79 years were included in the analyses. Information on immunisation history, as well as
behavioural and socio-demographic characteristics were collected. Anti-tetanus IgG, anti-diphtheria IgG and anti-HBs IgG were
measured by indirect enzyme-linked immunosorbent assay (ELISA). Odds ratios and 95% confidence intervals were calculated using
logistic regression. Atopic diseases were reported by 14% of participants. Proportions of 67%, 34% and 10% had been vaccinated
against tetanus, diphtheria and hepatitis B within the past ten years, respectively. Multi-variable analyses revealed no associations
between the presence of atopic diseases and all of the three vaccine-specific antibody titres. We conclude that there is no
reduced immune response related to antibody production following immunisations against tetanus, diphtheria and hepatitis B
in adults with atopic diseases. |
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