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长托宁用于神经外科术前准备的临床观察
引用本文:刘海根. 长托宁用于神经外科术前准备的临床观察[J]. 天津医药, 2005, 33(6): 358-359
作者姓名:刘海根
作者单位:300060,天津市脑系科中心医院麻醉科
摘    要:目的:观察选择性M-受体拮抗剂长托宁用于神经外科术前准备的临床效果。方法:选取神经外科择期手术60例,随机分为3组(每组20例):对照组(A组),不应用术前药;阿托品组(B组)和长托宁组(C组),分别于麻醉诱导前30min肌肉注射阿托品或长托宁0.01mg/kg,记录用药后诱导前患者口腔干燥程度,气管插管后5min至术毕拔管时气道分泌物量及心率。结果:诱导前B组患者的心率明显高于C组和A组,差异有统计学意义(P<0.05)。诱导前至气管插管后2h,B组和C组患者的气道分泌物明显少于A组(P<0.05)。术毕拔管时,B组患者的气道分泌物则多于C组(P<0.05)。结论:选择性新型M-受体拮抗剂长托宁用于神经外科手术术前用药临床效果优于阿托品。

关 键 词:术前准备 长托宁 临床观察 M-受体拮抗剂 神经外科择期手术 气道分泌物 神经外科手术 临床效果 气管插管 阿托品 肌肉注射 麻醉诱导 干燥程度 术前用药 C组 B组 患者 对照组 术前药 用药后 统计学 心率 拔管

Clinical Observation of Penehyclidine Hydrochloride as Premedication in Neurosurgery
LIU Haigen. Clinical Observation of Penehyclidine Hydrochloride as Premedication in Neurosurgery[J]. Tianjin Medical Journal, 2005, 33(6): 358-359
Authors:LIU Haigen
Affiliation:LIU Haigen Department of Anaesthesia,Tianjin Huanhu Hospital,Tianjin 300060,Chian
Abstract:Objective: To observe the clinical effects of selective receptor-M antagonist penehyclidine hydrochloride as premedication in neurosurgery. Methods: Sixty selective operation patients were randomly divided into three groups (n=20) which included control group (group I) with no adminsitration, atropine group (group II) with the injection of atropine 0.01mg/kg i.m. 30 min before anesthesia inducement, and penehyclidine hydrochloride group (group III) with the injection of penehyclidine hydrochloride 0.01 mg/kg i.m. 30 min before anesthesia inducement. Xerostomia degree from administration to induction, the volume of secretion in airway and the heart rate from 5 min after tracheal cannula insertion to extubation after operation were recorded. Results: Heart rate was significantly higher in group II than those in group III and group I after administration, and it was significantly different (P < 0.05). The volume of secretion in airway in group II and group III were obviously less than that in group I from induction to 2h after tracheal cannula insertion (P < 0.05). The volume of secretion in airway in group II was more than that in group III after operation and extubation (P < 0.05). Conclusion: Selective receptor-M antagonist penehyclidine hydrochloride is more effective than atropine as premedication in neurosurgery.
Keywords:premedication penehyclidine hydrochloride neurosurgical procedures atropine quinuclidines  
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