The 4G/5G polymorphism of the plasminogen activator inhibitor-1 gene is associated with severe preeclampsia |
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| Authors: | N Yamada T Arinami K Yamakawa-Kobayashi H Watanabe S Sohda H Hamada T Kubo H Hamaguchi |
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| Institution: | (1) Department of Obstetrics and Gynecology, Institute of Clinical Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan Tel. +81-298-53-3352; Fax +81-298-53-3333 e-mail: md965409@md.tsukuba.ac.jp, JP;(2) Department of Medical Genetics, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba Japan, JP |
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| Abstract: | Preeclampsia is associated with thrombosis of the intervillous or spiral artery. A deletion/insertion polymorphism (4G or
5G) in the promoter of the plasminogen activator inhibitor type 1 (PAI-1) gene is suggested to be involved in regulating the synthesis of the inhibitor, 4G allele, being associated with the enhanced
gene expression and plasma PAI-1 levels. We assessed the association between preeclampsia and the 4G/5G polymorphism of the
PAI-1 gene in 115 preeclamptic patients, 210 pregnant controls, and 298 healthy volunteer controls. The frequency of the homozygotes
for the 4G allele was significantly higher in the patients than in the control pregnant women (P = 0.04) or in the healthy volunteers (P = 0.02). The 4G allele frequency was also significantly higher in the patients than in the control group of pregnant women
(P = 0.03) and in the healthy volunteers (P = 0.02). These results suggest that the presence of the 4G/4G genotype of the PAI-1 gene is one of the risk factors for preeclampsia.
Received: October 14, 1999 / Accepted: January 4, 2000 |
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| Keywords: | Preeclampsia Plasminogen activator inhibitor type 1 Gene Polymorphism |
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