妊娠高血压疾病对子代脑氧饱和度的影响

目的 探讨妊娠高血压疾病对子代脑氧饱和度（rSO2）的影响,分析rSO2的相关因素.方法 通过近红外光谱（NIRS）测量120例产妇妊娠高血压疾病分娩新生儿的rSO2,与30例健康产妇分娩的足月顺产儿相比较,并监测其出生后情况、动脉血气分析、脉搏氧饱和度、颅脑B超等,比较两组间rSO2变化;对rSO2和上述指标进行相关分析与多因素分析.结果 产妇有妊娠高血压疾病的新生儿出生后3d内（不包括3d）rSO2明显低于对照组新生儿.以新生儿生后12 h rSO2为因变量,多元回归分析得到回归方程Y=0.335＋0.007X1＋ 0.001 X2＋0.004X3-0.041 X4（R =0.666,F=28.713,P=0.000）.结论 产妇妊娠高血压疾病可造成子代rSO2减低,rSO2与生后不同时间的颅脑B超结果呈负相关.评估新生儿脑损伤除头颅B超外,还需综合考虑其他危险因素.

Influence of maternal gestational hypertension during pregnancy on cerebral regional oxygen saturation of progeny

Objective To analyze the effect of maternal gestational hypertension during pregnancy on cerebral regional oxygen saturation （rSO2） of progeny and the correlated factors of rSO2.Methods The rSO2 detected by near infrared spectroscopy in 120 infants of maternal gestational hypertension during pregnancy was compared with that in 30 healthy full-term neonates.Arterial blood gas analysis,oxygen saturation by pulse and B-type ultrasonography of brain in the infants of maternal gestational hypertension during pregnancy were monitored.The correlation analysis and multi-factor analysis between the brain regional oxygen saturation and such factors were performed.Results The rSO2 in the infants of maternal gestational hypertension was significantly lower than that in control group.It also showed that if took rSO2 12 hour after birth as the dependent variable,multiple linear regression analysis concluded the linear regression equation as Y =0.335 ＋ 0.007X1 ＋ 0.001X2 ＋ 0.004X3-0.041X4（R =0.666,F =28.713,P =0.000）.Conclusion The rSO2 is lower in the infants of maternal gestational hypertension during pregnancy.The correlation analysis shows a negative correlation between rSO2 and B-type ultrasonography of brain.One should consider all of the above factors when assess the brain injury in newborn.