Photodynamic therapy of experimental tumours with Zn(II)-phthalocyanine and pulsed laser irradiation |
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| Authors: | M Shopova N Stoichkov A Milev M Peev K Georgiev A Gizbreht G Jori F Ricchelli |
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| Institution: | (1) Institute of Organic Chemistry, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria;(2) National Center of Oncology, 1156 Sofia, Bulgaria;(3) Institute of Electronics, Bulgarian Academy of Sciences, 1172 Sofia, Bulgaria;(4) C.N.R. Centre of Metalloproteins and Department of Biology, University of Padova, 35121 Padova, Italy |
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| Abstract: | The effectiveness of a pulsed dye laser (673 nm) for photodynamic therapy (PDT) of tumours in the presence of Zn(II)-phthalocyanine (ZnPc) was evaluated using Lewis lung carcinoma-bearing mice. The tumours were irradiated with different pulse energies (from 0.4 to 10 mJ) at a constant fluence of 0.6 J cm–2 at 24 h after administration of 0.25 mg kg–1 body weight liposome-incorporated ZnPc. Maximal PDT effect, as evaluated by changes in mean tumour diameter, animal survival time and histological evaluation of tumour necrosis, was observed after 3.0 mJ pulse energy irradiation which appears to yield a deeper light penetration and a more efficient sensitizer excitation when compared with lower or higher pulse energies. Electron microscopic analysis of photo-treated tumour indicates preferential damage to malignant tissue as compared to endothelial cells. |
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| Keywords: | Lewis lung carcinoma Liposomes Photodynamic therapy Pulsed laser irradiation Zn(II)-phthalocyanine |
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