| 去甲万古霉素链珠个体化治疗耐甲氧西林葡萄球菌感染的慢性骨髓炎的研究 |
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| 引用本文： | 庞晓军,黄粹业,陆茂德,易广田.去甲万古霉素链珠个体化治疗耐甲氧西林葡萄球菌感染的慢性骨髓炎的研究[J].中国药房,2010(20):1854-1855. |
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| 作者姓名： | 庞晓军 黄粹业 陆茂德 易广田 |
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| 作者单位： | 广西钦州市第二人民医院; |
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| 基金项目： | 钦州市科学研究与技术开发计划项目(20094108) |
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| 摘 要： | 目的:探索治疗耐甲氧西林葡萄球菌(MRS)感染的慢性骨髓炎的新途径。方法:选择确诊为MRS感染的慢性骨髓炎患者27例,将其随机分为2组,术前均静脉滴注去甲万古霉素防止感染,试验组(15例)以去甲万古霉素链珠(去甲万古霉素与骨水泥混合物)填充缺损处;对照组(12例)仅以骨水泥填充缺损处。比较2组感染治愈率、治愈感染所需抗生素治疗成本、不良反应发生率、治愈所需时间。结果:2组治疗MRS感染的慢性骨髓炎皆有效,但试验组不良反应发生率和抗生素治疗成本较低,同时控制感染也较快。结论:采用去甲万古霉素链珠个体化治疗MRS感染的慢性骨髓炎优于仅静脉给予去甲万古霉素的治疗方法。
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| 关 键 词： | 耐甲氧西林葡萄球菌 慢性骨髓炎 骨水泥 去甲万古霉素 临床药师 |
Study on Individual Norvancomycin Chain Bead Regimen in the Treatment of Methicillin-resistance Staphylococcus Infection Chronic Osteomyelitis |
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| PANG Xiao-jun,HUANG Cui-ye,LU Mao-de,YI Guang-tian.Study on Individual Norvancomycin Chain Bead Regimen in the Treatment of Methicillin-resistance Staphylococcus Infection Chronic Osteomyelitis[J].China Pharmacy,2010(20):1854-1855. |
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| Authors: | PANG Xiao-jun HUANG Cui-ye LU Mao-de YI Guang-tian |
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| Institution: | PANG Xiao-jun,HUANG Cui-ye,LU Mao-de,YI Guang-tian(Qinzhou Municipal Second People\'s Hospital of Guangxi,Qinzhou 535000,China) |
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| Abstract: | OBJECTIVE:To explore new therapy regimen for methicillin-resistance staphylococcus infection chronic osteomyelitis. METHODS:27 patients with methicillin-resistance staphylococcus infection chronic osteomyelitis were randomly divides into 2 groups. Both groups were injected with norvancomycin intravenously before operation to prevent infection. Norvancomycin chain bead (NCB) which were made from norvancomycin and bone cement was used to make up bone defect in NCB group(15 patients). Bone cement was used to m... |
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| Keywords: | Methicillin-resistance staphylococcus Chronic osteomyelitis Bone cement Norvancomycin Clinical pharmacist |
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