健脾行气化瘀汤治疗Hp阳性慢性萎缩性胃炎临床研究

目的:观察健脾行气化瘀汤治疗幽门螺杆菌(helicobacter pylori,Hp)阳性慢性萎缩性胃炎的临床疗效。方法:60例Hp阳性慢性萎缩性胃炎患者随机分为观察组和对照组,每组各30例。对照组给予"四联"疗法加胃复春片口服。观察组在"四联"疗法基础上,加用健脾行气化瘀汤,方药组成:黄芪15 g,党参15 g,茯苓12 g,炒白术15 g,砂仁10 g,丹参10 g,陈皮9 g,三七粉(冲服)3 g,薏苡仁15 g,厚朴10 g,山楂10 g,甘草10 g,水煎服,日2次;胃脘疼痛者加川楝子12 g,延胡索15 g;饱胀痞闷者加佛手15 g,玫瑰花10 g;嗳气纳差者加沉香6 g,旋覆花15 g;睡眠差者加炒酸枣仁20 g,制远志12 g;嘈杂反酸者加乌贼骨20 g,煅瓦楞子20 g;舌质暗红有瘀斑者加蒲黄10 g,五灵脂12 g。治疗后,比较两组患者临床疗效、临床症状积分、胃镜下表现积分及病理结果积分。结果:观察组、对照组有效率分别为86.21%和72.41%,两组比较,差异有统计学意义(P0.05)。两组治疗后临床症状积分均较治疗前明显降低(P0.05),且观察组各症状评分均明显低于对照组(P0.05)。两组患者治疗后胃镜下积分、病理结果积分比较,差异均有统计学意义(P0.05)。结论:健脾行气化瘀汤治疗Hp阳性慢性萎缩性胃炎临床疗效显著。

Clinical Study on Treatment of Hp Positive Chronic Atrophic Gastritis with Jianpi Xingqi Huayu Tang

Objective:To observe the clinical effect of Jianpi Xingqi Huayu Tang treatment of Helicobacter pylori (Hp) positive chronic atrophic gastritis.Methods:60 patients with Hp positive chronic atrophic gastritis were randomly divided into the observation group and the control group,30 cases in each group.The control group was given quadruple therapy plus Weifuchun orally.The observation group was additionally treated with Jianpi Xingqi Huayu Tang,composition:Huangqi (Astragalus) 15 g,Dangshen (Codonopsis) 15 g,Fuling (Poria Cocos) 12 g,Chaobaizhu (Fried Atractylodes) 15 g,Sharen (Amomum Villosum) 10 g,Danshen (Salviae Miltiorrhizae) 10 g,Chenpi (Dried Tangerine Peel) 9 g,Sanqifen (Notoginseng Powder) (blunt) 3 g,Yiyiren (Semen Coicis) 15 g,Houpu (Magnolia Officinalis) 10 g,Shanzha (Hawthorn) 10 g,Gancao (Liquorice) 10 g,water decoction,daily 2 times.Stomach pain with Chuanlianzi (Melia Toosendan) 12 g,Yanhusuo (Rhizoma Corydalis) 15 g;fullness and stuffy feeling with Foshou (Fingered Citron) 15 g,Meiguihua (Rose) 10 g;belching and poor appetite,with Chenxiang (Agilawood) 6 g,Xuanfuhua (Inula Flower) 15 g;sleep disorders with Chaosuanzaoren(Fried Semen Ziziphi Spinosae) 20 g,Yuanzhi(Polygala) 12 g;the persons who are noisy anti acid in stomach,Wuzeigu (Cuttlefish Bone) 20 g,Duanwalengzi (Prepared Concha Arcae) 20 g;the persons who have dark red tongue with ecchymosis,Puhuang(Cattail Pollen) 10 g,Wulingzhi(Trogopterus Dung) 12 g.After treatment,compared two groups of patients clinical curative effect,clinical symptoms integral,performance integral under gastroscope and pathology results.Results:The effective rate of the two groups were 86.21％ and 72.41％,and the difference was statistically significant (P ＜ 0.05).Two groups of clinical symptom scores after treatment were significantly lower than those before treatment (P ＜ 0.05),and the symptom score of observation group were significantly lower than the control group (P ＜ 0.05).After treatment,compared endoscopic integration and pathological results of the two groups of patients showed that the difference was statistically significant (P ＜ 0.05).Conclusion:The clinical curative effect of Jianpi Xingqi Huayu Tang in the treatment of Hp positive chronic atrophic gastritis is significant.