补益肺肾、化痰祛瘀法治疗急性加重期慢性阻塞性肺疾病临床研究

目的:观察补益肺肾、化痰祛瘀法治疗急性加重期慢性阻塞性肺疾病的临床疗效。方法:124例慢性阻塞性肺疾病急性加重期的患者随机分为对照组和观察组各62例。对照组应用沙丁胺醇、布地奈德及异丙托溴铵雾化吸入治疗,观察组在对照组治疗基础上给予自拟补肾化痰祛瘀方加减治疗。比较两组患者治疗前后中医证候积分及肺功能,并比较治疗后临床疗效。结果:两组患者治疗前中医证候积分比较,差异无统计学意义(P0.05);观察组患者治疗后中医证候积分优于对照组(P0.05)。两组患者治疗前PaO_2和PaCO_2比较,差异无统计学意义(P0.05);观察组患者治疗后PaO_2和PaCO_2优于对照组(P0.05)。两组患者治疗前第1秒用力呼气量(forced expiratory volume at one second,FEV1)%及FEV1/用力肺活量(forced vital capacity,FVC)比较,差异无统计学意义(P0.05);观察组患者治疗后FEV1%及FEV1/FVC(%)优于对照组(P0.05)。对照组有效率为80.6%,观察组有效率为95.2%,两组有效率比较,差异有统计学意义(P0.05)。结论:补益肺肾、化痰祛瘀法治疗急性加重期慢性阻塞性肺疾病可有效改善患者的症状体征,改善肺功能,效果显著。

Clinical Study on Invigorating Lung and Kidney,Resolving Phlegm and Removing Stasis Method Treatment of Acute Exacerbation of Chronic Obstructive Pulmonary Disease

Objective:To explore the effect of invigorating lung and kidney,resolving phlegm and removing stasis method treatment of acute exacerbation of chronic obstructive pulmonary disease.Methods:124 cases of patients with acute exacerbation of chronic pulmonary were randomly divided into the control group and the study group with 62 cases in each group.The control group was given salbutamol,budesonide and ipratropium bromide inhalation therapy,and the study group was treated with modified Bushen Huatan Quyu decoction based on the control group.Results:Comparison TCM syndrome score of the two groups of patients before treatment showed that the difference was not statistically significant (P ＞ 0.05);TCM syndrome score in the patients of observation group after treatment was better than that of control group (P ＜ 0.05).There was no significant difference in PaO2 and PaCO2 between the two groups before treatment (P ＞ 0.05),and PaO2 and PaCO2 in the observation group after treatment were better than that in the control group (P ＜ 0.05).There was no significant difference (P ＞ 0.05) between the two groups before treatment in FEV1％ and FEV1/FVC (％),and after treatment,the two groups were compared with FEV1％ and FEV1/FVC (％),the study group was better than the control group (P ＜ 0.05).The effective rate was 80.6％ in the control group,better than that of the control group 95.2％ (P ＜ 0.05).Conclusion:Invigorating lung and kidney,resolving phlegm and removing stasis method treatment of acute exacerbation of chronic obstructive pulmonary disease can effectively improve the symptoms and signs of patients,improve lung function,and the effect is significant.