补肾调经汤治疗多囊卵巢综合征所致不孕临床研究

目的:观察补肾调经汤治疗多囊卵巢综合征肾虚证所致不孕的临床疗效。方法:将89例多囊卵巢综合征肾虚证所致不孕患者按照随机分组法分为治疗组46例和对照组43例。对照组给予常规西药治疗,治疗组在对照组基础上加补肾调经汤治疗。两组患者疗程均为3个月经周期。比较两组患者临床疗效、激素水平、排卵情况、妊娠情况、卵巢体积、子宫内膜厚度和不良反应情况。结果:治疗组有效率为93.48%,对照组有效率为69.77%,两组比较,差异有统计学意义(P0.05);两组患者雌二醇(estradiol,E_2)、卵泡刺激素(follicle-stimulating hormone,FSH)治疗后水平较治疗前无明显变化,差异无统计学意义(P0.05),而促黄体生成素(luteinizing hormone,LH)治疗后较治疗前显著减少,差异有统计学意义(P0.05),治疗组LH治疗后显著低于对照组,而E_2、FSH治疗后水平较对照组无明显变化,差异无统计学意义(P0.05);治疗组排卵率为89.13%,对照组排卵率为72.09%,两组比较,差异有统计学意义(P0.05);治疗组妊娠率为86.96%,对照组妊娠率为55.81%,两组比较,差异有统计学意义(P0.05);两组卵巢体积治疗后较治疗前显著减少,差异有统计学意义(P0.05);子宫内膜厚度较治疗前显著增加,差异有统计学意义(P0.05);治疗组卵巢体积显著小于对照组,差异有统计学意义(P0.05);子宫内膜厚度显著高于对照组,差异有统计学意义(P0.05)。结论:补肾调经汤治疗多囊卵巢综合征肾虚证所致不孕临床疗效显著,补肾调经汤能够明显提高治疗疗效,降低LH水平,提高患者排卵和妊娠,增加子宫内膜厚度,减小卵巢体积,且未见明显不良反应。

Clinical Study on Bushen Tiaojing Decoction in Treatment of Infertility Caused by Polycystic Ovary Syndrome

Objective:To observe the clinical curative effect of Bushen Tiaojing Decoction on infertility caused by polycystic ovary syndrome.Methods:Forty-eight patients with infertility with polycystic ovary syndrome were randomly divided into treatment group (n =46) and control group(n =43).The control group was given conventional western medicine treatment;the treatment group was given Bushen Tiaojing Decoction in addition of control group.Two groups of patients were treated for 3 menstrual cycles.The clinical efficacy,hormone levels,ovulation conditions,pregnancy status,ovarian volume,endometrial thickness and adverse reactions were compared between the two groups.Results:The effective rate was 93.48％ in the treatment group and 69.77％ in the control group.The difference was statistically significant(P ＜ 0.05).The levels of E2 and FSH in the two groups were not significantly different from those before treatment (P ＜ 0.05).After treatment,the level of LH was significantly lower than that of the control group(P ＜ 0.05),but the level of E2 and FSH was no significantly changes than that of the control group(P ＞ 0.05).The ovulation rate in the treatment group was 89.13％,and the ovulation rate in the control group was 72.09％.There was significant difference between the two groups(P ＜0.05).The pregnancy rate was 86.96％ in treatment group and the control group had a pregnancy rate of 55.81％.There was significant difference between the two groups (P ＜ 0.05).The ovarian volume of the two groups was significantly lower than that before treatment(P ＜ 0.05).The thickness of endometrium was significantly higher than that of control group and that before treatment(P ＜ 0.05).Conclusion:Bushen Tiaojing Decoction can effectively improve the curative effect,reduce the level of LH,improve the ovulation and pregnancy,increase the thickness of endometrium and reduce the ovarian volume with no obvious adverse reactions.