加味四妙散口服联合四黄散加味外敷治疗痛风性关节炎临床研究

目的:观察加味四妙散口服联合四黄散加味外敷治疗痛风性关节炎的临床疗效。方法:选择痛风性关节炎患者100例为研究对象,随机分为观察组和对照组,各50例。其中观察组采用加味四妙散口服,四黄散加味外敷治疗,对照组患者采用常规西药治疗。于治疗后对两组患者的临床疗效进行综合评价。结果:观察组临床有效率为94.00%(47/50),对照组为76.00%(38/50),两组比较,差异有统计学意义(P0.05)。观察组生理指标包括血尿酸(uric acid,UA)、C反应蛋白(C reactive protein,CRP)、血沉(erythrocyte sedimentation rate,ESR)水平分别为(354.87±30.27)μmol·L~(-1)、(10.64±2.01)mg·L~(-1)、(19.26±4.89)mm·h~(-1),对照组分别为(420.19±39.58)μmol·L~(-1)、(13.37±2.42)mg·L~(-1)、(24.20±4.71)mm·h~(-1),两组比较,差异有统计学意义(P0.05),提示观察组的生理指标改善情况良好。观察组不良反应发生率为2.00%(1/50),对照组为18.00%(9/50),两组比较,差异有统计学意义(P0.05),提示观察组治疗方法安全性良好。观察组在治疗后及随访12个月时,患者疼痛视觉模拟评分(visual analogue score,VAS)分别为(4.62±1.09)分、(1.58±0.34)分,显著低于对照组的(5.94±1.37)分、(1.95±0.41)分,提示观察组对疼痛改善效果更好。结论:加味四妙散口服联合四黄散加味外敷对痛风性关节的治疗效果显著,能够提高临床疗效,改善患者的各项生理指标,有效缓解患者的疼痛感,且用药安全性好。

Clinical Study on Modified Simiao Powder Combined with Modified Sihuang Powder in Treatment of Gouty Arthritis

Objective:To observe the clinical effect of Modified Simiao Powder combined with Modified Sihuang Powder in treatment of gouty arthritis.Methods:100 patients with gouty arthritis were randomly divided into observation group and control group.The observation group was treated with Modified Simiao Powder combined with Modified Sihuang Powder,while the control group of patients was treated with conventional western medicine.After the treatment the clinical efficacy of the two groups of patients was comprehensively evaluated.Results:The clinical effective rate in the observation group was 94.00％ (47/50) and that in the control group was 76.00％ (38/50).The difference was statistically significant (P ＜ 0.05).The levels of uric acid (UA),C reactive protein (CRP) and Erythrocyte sedimentation rate (ESR) in the observation group were (354.87 ± 30.27) μmol · L-1,(10.64 ± 2.01)mg · L-1 and (19.26 ± 4.89) mm · h-1 respectively,and that of the control group were (420.19 ± 39.58) umol · L-1,(13.37 ± 2.42) mg · L-1 and (24.20 ± 4.71) mm · h-1,with the differences between the two groups being statistically significant (P ＜ 0.05),suggesting that the treatment efficacy of the observation group was better.The incidence of adverse reactions in the observation group was 2.00％ (1/50) and that in the control group was 18.00％ (9/50),and the difference was statistically significant (P ＜ 0.05),suggesting that the safety of the observation group was better.In the observation group,the visual analogue score (VAS) of the observation group was (4.62 ± 1.09) and (1.58 ±0.34) points respectively,and that was significantly lower than that of the control group,namely,(5.94 ± 1.37) and (1.95 ± 0.41) points,respectively,suggesting that the pain relieving effect of the observation group was better.Conclusion:The clinical effect of Modified Simiao Powder combined with Modified Sihuang Powder in treatment of gouty arthritis is significant,which can improve the clinical efficacy,improve patients' physiological indicators and relieve the pain of patients effectively,with satisfying treatment safety.