宣痹通阳汤治疗冠心病心绞痛室性期前收缩临床研究

目的:观察自拟宣痹通阳汤治疗冠状动脉粥样硬化性心脏病(简称冠心病)心绞痛室性期前收缩的临床疗效。方法:146例冠心病心绞痛室性期前收缩患者随机分为对照组和观察组。对照组患者给予基础治疗+琥珀酸美托洛尔治疗。观察组在对照组治疗基础上给予自拟宣痹通阳汤。比较治疗前后两组患者临床症状、24小时室性期前收缩次数、左心室射血分数、左心室缩短分数及生存质量的变化情况及不良反应发生率,并对两组患者进行疗效评价。结果:治疗后,观察组证候积分为(8.54±1.75)分,对照组为(14.58±1.57)分,两组比较,差异有统计学意义(P0.05);观察组24小时室性期前收缩次数(1458.89±107.56)次,对照组为(1857.68±114.57)次,两组比较,差异有统计学意义(P0.05);观察组有效率为95.79%,对照组为79.45%,两组比较,差异有统计学意义(P0.05);观察组左心室射血分数、左心室缩短分数分别为(55.24±1.67)%、(28.06±1.33)%,对照组分别为(49.87±1.23)%、(25.03±1.43)%,两组比较,差异均有统计学意义(P0.05);观察组心理健康、躯体活动、生理健康、社会关系评分分别为(23.21±1.54)分、(22.24±1.49)分、(23.47±1.57)分、(22.88±1.58)分,对照组分别为(20.35±1.69)分、(19.58±1.35)分、(20.57±1.38)分、(19.68±1.52)分,两组比较,差异均有统计学意义(P0.05)。结论:自拟宣痹通阳汤治疗冠心病心绞痛室性期前收缩疗效显著,可缓解临床症状,降低中医证候积分,减少24小时室性期前收缩次数,提高左心室射血分数、左心室缩短分数,提高生存质量评分。

Clinical Study on Xuanbi Tongyang Decoction in Treatment of Coronary Heart Disease Angina Ventricular Contractions

Objective:To observe the clinical effect of Xuanbi Tongyang Decoction in treatment of Coronary heart disease angina ventricular contractions.Methods:146 patients with coronary heart disease and angina pectoris were randomly divided into control group and observation group.Patients in the control group were treated with basal therapy + metoprolol succinate.Observation group in the control group were given Xuanbi Tongyang Decoction in addition to that of the control group.The changes of clinical symptoms,24-hour ventricular premature beats,left ventricular ejection fraction,left ventricular shortening score and quality of life of both groups before and after treatment were compared,and the curative effect of the two groups was evaluated.Results:After treatment,the symptom scores of the observation group were (8.54 ± 1.75) and that of the control group were (14.58 ± 1.57).The difference was statistically significant (P ＜ 0.05).The 24-hour contractions times before ventricular phase of the observation group were (1458.89 ± 107.56),and that of the control group were (1857.68-± 114.57) times.The difference between the two groups was statistically significant (P ＜ 0.05).The effective rate of observation group was 95.79％ and that of the control group was 79％.The left ventricular ejection fraction and left ventricular shortening score of the observation group were (55.24 ± 1.67) and (28.06 ± 1.33) and that of the control group were (49.87 ± 1.23) and (25.03 ± 1.43).The difference was statistically significant (P ＜ 0.05).The scores of physical health,physical activity,physical health and social relationship of the observation group were (23.21 ± 1.54),(22.24 ± 1.49),(23.47 ± 1.57) and (22.88 ± 1.58) respectively,and that of the control group were (20.35 ± 1.69),(19.58 ± 1.35),(20.57 ± 1.38) and (19.68 ± 1.52) respectively.The difference was statistically significant (P ＜ 0.05).Conclusion:Xuanbi Tongyang Decoction can significantly relieve the clinical symptoms,reduce the score of TCM syndrome,reduce the number of ventricular premature ventricular contractions,increase the left ventricular ejection fraction,and increase the left ventricular ejection fraction Ventricular shortening scores of patients and improve their quality of life score.