Worldwide Dissemination of the blaOXA-23 Carbapenemase Gene of Acinetobacter baumannii1 |
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| Authors: | Pauline D Mugnier Laurent Poirel Thierry Naas and Patrice Nordmann |
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| Institution: | Institut National de la Santé et de la Recherche Médicale Unité 914, Paris, France;Université Paris Sud, Bicêtre, France;1This work was presented in part at the 19th European Congress of Clinical Microbiology and Infectious Diseases, Helsinki, Finland, May 16–19, 2009. |
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| Abstract: | To assess dissemination of OXA-23–producing strains of Acinetobacter baumannii, we obtained 20 carbapenem-resistant, OXA-23–producing isolates from different regions. Their clonal relationship was assessed by pulsed-field gel electrophoresis and multilocus sequence typing. We identified 8 sequence types, including 4 novel types. All except 2 strains belonged to 2 main European clonal lineages. The blaOXA-23 gene was either located on the chromosome or on plasmids and associated with 4 genetic structures. |
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| Keywords: | Acinetobacter baumannii oxacillinase carbapenems Tn2006 ISAba1 bacteria zoonoses infectious diseases vector-borne infections research |
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