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| 端粒酶活性与Bcl-2蛋白在胃癌及癌旁组织中表达及其意义 | |
| 引用本文： | 王景毅,金晓明,赵绍光,张朋旗,贺岩,钟志玖. 端粒酶活性与Bcl-2蛋白在胃癌及癌旁组织中表达及其意义[J]. 黑龙江医学, 2003, 27(2): 97-98 |
| 作者姓名： | 王景毅 金晓明 赵绍光 张朋旗 贺岩 钟志玖 |
| 作者单位： | 1. 黑龙江省医院普外科,黑龙江,哈尔滨,150036 2. 哈尔滨医科大学病理教研室,黑龙江,哈尔滨,150080 3. 辽阳解放军203医院普外科,辽宁,辽阳,150036 |
| 摘 要： | 目的 探讨端粒酶活性和Bcl - 2蛋白表达在胃癌及癌旁组织中的作用。方法 应用原位杂交技术和免疫组织化学方法 ,对 32例胃癌组织进行了端粒酶 -mRNA和Bcl- 2蛋白的检测。结果 端粒酶 -mR NA和Bcl- 2蛋白表达在胃癌组织内表达率很低 ,两者无负相关性。端粒酶在胃印戒细胞癌组织内过表达。Bcl- 2在胃黏膜的淋巴滤泡和淋巴组织内过表达。结论 端粒酶活性激活与Bcl- 2蛋白表达在胃癌组织内无负相关性。 |
| 关 键 词： | 肿瘤学 胃癌 端粒酶 癌旁组织 Bcl-2蛋白 |
| 文章编号： | 1004-5775(2003)02-0097-02 |
| 修稿时间： | 2003-01-06 |
Telomerase Activity and Expression of Bcl-2 Protein in Gastric carcinoma and Paracancerous Tissue |
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| Abstract: | Objective To investigate the telomerase activity and the expression of Bcl-2 protein in gastric carcinoma and paracancerous tissue. Methods Telomerase activity and Bcl-2 protein of 32 cases gastric carcinoma tissue were detected by in situ hybridization and immunochemical method.Results Telomerase mRNA and Bcl-2 protein were low expression in gastric carcinoma tissue, and the two matter were not negative correlation. Telomerase was over expression in gastric signet-ring cell carcinoma. Bcl-2 protein was over expression in lymph tissue and lymph follicle of stomach. Conclusion Telomerase activity and expression of Bcl-2 protein were not negative correlation in gastric carcinoma. |
| Keywords: | Oncology Gastric carcinoma Paracancerous tissue Telomerase Bcl-2 protein |
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