| 毛蕊花苷对骨骼肌中氧自由基和脂质过氧化物的清除和抑制效应 |
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| 引用本文： | 李静先 辛东. 毛蕊花苷对骨骼肌中氧自由基和脂质过氧化物的清除和抑制效应[J]. 中国药理学报, 1999, 20(2): 126-130 |
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| 作者姓名： | 李静先 辛东 |
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| 摘 要： |
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| 关 键 词： | 毛蕊花苷 骨骼肌 氧自由基 脂质过氧化物 清除 |
Effect of verbascoside on decreasing concentration of oxygen free radicals and lipid peroxidation in skeletal muscle. |
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| J X Li,D Xin,H Li,J F Lu,C W Tong,J N Gao,K M Chan. Effect of verbascoside on decreasing concentration of oxygen free radicals and lipid peroxidation in skeletal muscle.[J]. Acta Pharmacologica Sinica, 1999, 20(2): 126-130 |
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| Authors: | J X Li D Xin H Li J F Lu C W Tong J N Gao K M Chan |
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| Affiliation: | Department of Orthopedics & Traumatology, Chinese University of Hong Kong, China. lijx@HKSDB.ORG.HK |
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| Abstract: | AIM: To detect the effects of verbascoside on decreasing the concentration of oxygen free radicals (OFR) and lipid peroxidation in skeletal muscle resulting from exhaustive exercise. METHODS: Electron spin resonance (ESR) technique and thiobarbituric acid reaction (TBAR) method were used to detect the concentration of OFR in intact gastrocnemius muscle and the contents of milondialdehyde (MDA) in muscle homogenate. RESULTS: Verbascoside decreased the concentration of OFR (P < 0.05) and the level of lipid peroxidation (P < 0.05) in muscle caused by exercise. CONCLUSION: Verbascoside has the effects of reducing oxidative stress in muscle caused by exhaustive exercise by decreasing the concentration of free radicals and the level of lipid peroxidation. |
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