| 粉防己碱对肺动脉平滑肌细胞钙激活钾通道的双重作用 |
| |
| 引用本文： | 王中峰,开丽.粉防己碱对肺动脉平滑肌细胞钙激活钾通道的双重作用[J].中国药理学报,1999,20(3):253-256. |
| |
| 作者姓名： | 王中峰 开丽 |
| |
| 作者单位： | [1]第三军医大学生理学教研室 [2]重庆药理学教研室 |
| |
| 摘 要： | 目的：研究粉防己碱（Ｔｅｔ）对大鼠肺动脉平滑肌细胞钙激活钾（Ｋｃａ）通道的影响。方法 内面朝外膜片箝单通道记录法，结果：Ｔｅｔ７．５和１５μｍｏｌ．Ｌ＾－１使Ｋｃａ的开放概率由０．２５１±０．０１２增加到０．３４０±０．０１３和０．４１５±０．０１１（Ｐ〈０．０１），关闭时间由（６１±１５）ｍｓ缩短到（３３±１０）和（２８±１１）ｍｓ（Ｐ〈０．０１）Ｔｅｔ３０μｍｏｌ．Ｌ＾－１使开放概率和开放时间
|
| 关 键 词： | 粉防己碱 离子通道 钾通道 肺动脉 平滑肌细胞 |
Dual effects of tetrandrine on calcium-activated potassium channels in pulmonary artery smooth muscle cells. |
| |
| Z F Wang,L Kai,X R Xiao.Dual effects of tetrandrine on calcium-activated potassium channels in pulmonary artery smooth muscle cells.[J].Acta Pharmacologica Sinica,1999,20(3):253-256. |
| |
| Authors: | Z F Wang L Kai X R Xiao |
| |
| Institution: | Department of Physiology, Third Military Medical University, Chongqing, China. |
| |
| Abstract: | AIM: To study the effects of tetrandrine (Tet) on calcium-activated potassium channels. METHODS: Inside-out configuration of patch-clamp single channel recording techniques. RESULTS: Tet 7.5 and 15 mumol.L-1 increased the open probability from control value 0.251 +/- 0.012 to 0.340 +/- 0.013 and 0.415 +/- 0.011, respectively (P < 0.01), decreased the close time from (61 +/- 15) ms to (33 +/- 10) and (28 +/- 11) ms, respectively (P < 0.01). But Tet 30 mumol.L-1 decreased the open probability and open time to (0.114 +/- 0.008) and (1.47 +/- 0.09) ms, respectively P < 0.01 vs control (0.251 +/- 0.012) and (20 +/- 8) ms]. CONCLUSION: Tet has concentration-dependent dual effects on KCa channels in isolated rat pulmonary smooth muscle cells. |
| |
| Keywords: | |
| 本文献已被 维普 等数据库收录！ |
|
