莫索尼定对麻醉大鼠颈动脉窦压力感受器反射的影响

观察莫索尼对颈动脉窦压力感受器反射的影响。方法：利用灌流左颈动脉窦方法，观察莫索尼定对麻醉大鼠压力反射机能参数的影响。恒流灌流股动脉，记录灌流压变化，确定莫索尼定对血管阻力的影响。结果；莫索尼定３２．１００μｍｏｌ．Ｌ＾－１使颈动脉窦压力反射机能曲线向右上移位，曲线最大斜率和反射性平均动脉压下降幅度均减小，提示莫索尼定对压力感受器反射有抑制作用。

Effect of moxonidine on carotid sinus baroreflex in anesthetized rats.

AIM: To study the effect of moxonidine (Mox) on carotid sinus baroreflex. METHODS: By perfusing the carotid sinus in anesthetized rats, the functional parameters of baroreflex were measured. The femoral artery was perfused with constant flow and the change of perfusing pressure was recorded to determine the effect of Mox on vascular tone. RESULTS: Mox 32 and 100 mumol.L-1 shifted the functional curve of carotid sinus baroreflex to the right and upward, with the reduction in peak slope and in reflex decrease of mean arterial pressure, suggesting that Mox produced an inhibitory effect on baroreflex. The effect of Mox 100 mumol.L-1 on baroreflex was completely blocked by efaroxan 100 mumol.L-1. Mox increased vascular resistance. CONCLUSION: Mox inhibits carotid baroreflex via its constrictive action on sinus wall.