| 依普黄酮固体分散的制备和溶出特性 |
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| 引用本文： | 李亚平,张贤英.依普黄酮固体分散的制备和溶出特性[J].中国药理学报,1999,20(10):957-960. |
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| 作者姓名： | 李亚平 张贤英 |
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| 摘 要： |
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| 关 键 词： | 依普黄酮 异黄酮 制剂 聚维酮 制备 溶出特性 |
Preparation and dissolution property of ipriflavone solid dispersion. |
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| Y P Li,X Y Zhang,J J Zhou,Y Y Pei.Preparation and dissolution property of ipriflavone solid dispersion.[J].Acta Pharmacologica Sinica,1999,20(10):957-960. |
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| Authors: | Y P Li X Y Zhang J J Zhou Y Y Pei |
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| Institution: | Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 200031, China. ypli@server.shcnc.ac.cn |
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| Abstract: | AIM: To prepare and identify ipriflavone (IP) solid dispersion, and determine its dissolution property. METHODS: The solvent method was used for preparation and differential scanning calorimetry (DSC), X-ray diffraction and infrared spectrophotometry for identification of IP solid dispersion. The dissolution of the dispersion was determined with paddle method. RESULTS: The dissolution of IP solid dispersion consisting of IP and povidone-k30 (PVP) (1:8) in artificial gastric juice is 6.15 times as high as that of IP alone. The DSC curves, X-ray diffraction patterns and infrared spectrophotometries of IP have been changed obviously by the dispersion. CONCLUSION: The dissolution of IP is increased by solid dispersion method. |
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