| 合成白细胞介素—1阻滞药的全身性抗炎作用 |
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| 引用本文： | 邱春亿 刘学丽. 合成白细胞介素—1阻滞药的全身性抗炎作用[J]. 中国药理学报, 1999, 20(5): 405-408 |
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| 作者姓名： | 邱春亿 刘学丽 |
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| 摘 要： |
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| 关 键 词： | 角叉菜胶 炎症 非甾类消炎药 OB－101 阿司匹林 |
Systemic anti-inflammation by synthetic interleukin-1 blockers. |
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| G C Chiou,S X Liu. Systemic anti-inflammation by synthetic interleukin-1 blockers.[J]. Acta Pharmacologica Sinica, 1999, 20(5): 405-408 |
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| Authors: | G C Chiou S X Liu |
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| Affiliation: | Department of Medical Pharmacology and Toxicology, College of Medicine, Texas A & M University, College Station 77843, USA. gchiou@tamu.edu |
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| Abstract: | AIM: To study the systemic anti-inflammatory actions of interleukin-1 (IL-1) blockers, OB-101 and OB-186. METHODS: Prevention of palm swelling induced by carrageenin injection was used as an animal model of systemic anti-inflammation efficacy. RESULTS: Both OB-101 and OB-186 (10-30 mg.kg-1) were approximately 10-30-fold more potent than aspirin (300 mg.kg-1) to inhibit carrageenin-induced systemic inflammation. The LD50 of OB-101 and OB-186 were at least 20 g.kg-1 i.g., indicating that they were extremely safe agents with a therapeutic index (LD50/ED50) of at least 2000. CONCLUSION: These IL-1 blockers are extremely safe systemically and are useable for the treatment of systemic inflammation such as rheumatoid arthritis. |
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