| TMB—8抑制神经递质引起的单个脑细胞内游离钙的升高 |
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| 引用本文： | 张孝清 王斌. TMB—8抑制神经递质引起的单个脑细胞内游离钙的升高[J]. 中国药理学报, 1999, 20(10): 893-896 |
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| 作者姓名： | 张孝清 王斌 |
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| 摘 要： |
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| 关 键 词： | 脑细胞 游离钙 尼莫地平 谷氨酸钠 血清素 药理 |
Inhibitory effects of 8-(N,N-diethylamino)-n-octyl-3,4,5-trimethoxybenzoate (TMB-8) on intracellular Ca2+ elevated by neurotransmitters in brain cells. |
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| X Q Zhang,B Wang,M Y Zhang,J G Xiao. Inhibitory effects of 8-(N,N-diethylamino)-n-octyl-3,4,5-trimethoxybenzoate (TMB-8) on intracellular Ca2+ elevated by neurotransmitters in brain cells.[J]. Acta Pharmacologica Sinica, 1999, 20(10): 893-896 |
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| Authors: | X Q Zhang B Wang M Y Zhang J G Xiao |
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| Affiliation: | Department of Pharmacology, Nanjing Medical University, Nanjing 210029, China. |
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| Abstract: | AIM: To study the effects of TMB-8 on [Ca2+]i elevation induced by neurotransmitters in dissociated brain cells. METHODS: The brain cell suspension was made using a gentle trituration for 1 min with a polished pipette. The changes of [Ca2+]i were detected by the fluorescent indicator, Fura 2-AM. RESULTS: In the presence of extracellular Ca2+ 1.3 mmol.L-1, sodium glutamate (Glu), histamine (His), and serotonin (5-HT) markedly increased the [Ca2+]i which were reduced by TMB-8 30 mumol.L-1. TMB-8 3 mumol.L-1 produced inhibitory effects on the increase of [Ca2+]i by His and 5-HT in a Ca(2+)-free Hanks' solution. The increase of [Ca2+]i by His and 5-HT was reduced to control level by TMB-8 10 mumol.L-1. CONCLUSION: TMB-8 inhibited the [Ca2+]i elevation induced by Glu, 5-HT, and His in brain cells. |
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