~(131)I与抗甲状腺药物治疗Graves甲亢的疗效评价

目的:评价131I与抗甲状腺药物(ATD)治疗Graves甲亢的疗效。方法:520例甲亢患者随机分为2组,分别采用131I和ATD治疗,并随访5年,观察疗效和不良反应。结果:131I治疗Graves甲亢的疗效优于ATD;Graves甲亢治愈后复发明显低于ATD治疗,出现甲亢性心脏病、血象、肝功能受损等方面低于ATD,两者发生突眼率的差异无统计学意义。但131I治疗后甲减的发生率高于ATD。结论:131I治疗Graves甲亢疗效明显优于ATD治疗。

The curative Effects of131I and ATD for patients with Graves hyperthyroidism

Objective ： To evaluate the treatment of Graves＇ hyperthyroidism with ^131I and ATD. Methods ：the 520 clinical patients with Graves＇ hyperthyroidism were collected. They were divided into 2 groups treated with ATD and ^l31I to compare the total curative effects. All patients were followed up for 5 years. Results.. The curative effect ^131I was better than that of ATD; the incidence of Graves＇ ophthalmopathy in two groups was not significantly different. The patients cured with ^131I had the less Graves＇ hyperthyroidism relapse than those with ATD. In the patients treated with ^131I the incidence of hyperthyroid heart disease; liver function damage, leukopenia and so on were less than those treated with ATD. But the Graves＇ hyperthyroidism patients treated with ^131I got the higher incidence rate of hypothyroidism. Conclusions ： ^131I therapy excels the ATD in the treatment of the patients with Graves＇ hyperthyroidism.