~(131)I与抗甲状腺药物治疗Graves甲亢的疗效评价 |
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引用本文: | 黄诚,李玮,胡斌,曹小征,王锦锋. ~(131)I与抗甲状腺药物治疗Graves甲亢的疗效评价[J]. 陕西医学杂志, 2009, 38(6): 676-677 |
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作者姓名: | 黄诚 李玮 胡斌 曹小征 王锦锋 |
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作者单位: | 河南科技大学第一附属医院核医学科,洛阳,471003 |
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摘 要: | 目的:评价131I与抗甲状腺药物(ATD)治疗Graves甲亢的疗效。方法:520例甲亢患者随机分为2组,分别采用131I和ATD治疗,并随访5年,观察疗效和不良反应。结果:131I治疗Graves甲亢的疗效优于ATD;Graves甲亢治愈后复发明显低于ATD治疗,出现甲亢性心脏病、血象、肝功能受损等方面低于ATD,两者发生突眼率的差异无统计学意义。但131I治疗后甲减的发生率高于ATD。结论:131I治疗Graves甲亢疗效明显优于ATD治疗。
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关 键 词: | 甲状腺功能亢进症/放射疗法 碘放射性同位素/治疗应用 对比研究 |
The curative Effects of131I and ATD for patients with Graves hyperthyroidism |
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Affiliation: | Huang Cheng Li Wei Hu Bin et al(Department of Nuclear Medicine, The First Hospital Affiliated to Henan University of Science and Technology,Luoyang 471003) |
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Abstract: | Objective : To evaluate the treatment of Graves' hyperthyroidism with ^131I and ATD. Methods :the 520 clinical patients with Graves' hyperthyroidism were collected. They were divided into 2 groups treated with ATD and ^l31I to compare the total curative effects. All patients were followed up for 5 years. Results.. The curative effect ^131I was better than that of ATD; the incidence of Graves' ophthalmopathy in two groups was not significantly different. The patients cured with ^131I had the less Graves' hyperthyroidism relapse than those with ATD. In the patients treated with ^131I the incidence of hyperthyroid heart disease; liver function damage, leukopenia and so on were less than those treated with ATD. But the Graves' hyperthyroidism patients treated with ^131I got the higher incidence rate of hypothyroidism. Conclusions : ^131I therapy excels the ATD in the treatment of the patients with Graves' hyperthyroidism. |
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Keywords: | Hyperthyroidism/radiotherapy Iodine radioisotopes/therapeutic use Comparative study |
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