| 胃灵颗粒对胃癌前病变细胞凋亡基因影响的实验研究 |
| |
| 引用本文： | 谢晶日,李威,梁国英,杨丰源.胃灵颗粒对胃癌前病变细胞凋亡基因影响的实验研究[J].中国医药导报,2007,4(8):15-16. |
| |
| 作者姓名： | 谢晶日 李威 梁国英 杨丰源 |
| |
| 作者单位： | 黑龙江中医药大学附属第一医院消化一科,黑龙江哈尔滨,150040 |
| |
| 摘 要： | 目的:探讨中药冲剂胃灵颗粒对大鼠胃癌前病变(GPL)细胞凋亡基因表达的影响及其相关机制。方法:N-甲基N-硝基-N-亚硝基胍加饥饱失常法造大鼠GPL模型,用胃灵颗粒与维酶素治疗,观察对病变黏膜组织中Bcl-2、Bax、p53基因蛋白水平的影响。结果:中药组治疗后Bcl-2、Bax、p53基因蛋白阳性指数明显低于病理对照组(P<0.05)。结论:健脾养阴活血为主的胃灵颗粒通过改善GPL大鼠气阴两虚兼挟血瘀的病理基础,降低病变组织增殖水平,诱导细胞正常凋亡,从而对GPL细胞的增殖有良好的阻断作用。
|
| 关 键 词： | 胃癌前病变 胃灵颗粒 细胞凋亡 |
| 文章编号： | 1673-7210(2007)03(b)-015-02 |
| 修稿时间： | 2007年2月5日 |
Experiment study on effects of Weiling Granules on apoptosis gene in gastric precancerous lesion |
| |
| XIE Jing-ri,LI Wei,LIANG Guo-ying,YANG Feng-yuan.Experiment study on effects of Weiling Granules on apoptosis gene in gastric precancerous lesion[J].China Medical Herald,2007,4(8):15-16. |
| |
| Authors: | XIE Jing-ri LI Wei LIANG Guo-ying YANG Feng-yuan |
| |
| Abstract: | Objective:To study the effects of Weiling Granules on apoptosis gene in gastric precancerous lesion of rat. Methods:In animal experiment, precancerous lesions of gastric models were induced by MNNG in Wistar rats.The rats were treated by Weiling Granules and Wei Mei Su Pian, changes in expression of Bcl-2,Bax,p53 in slices of precancerous morbid tissues of gastric mucosa were measured by immuohistochemistry after using the drugs.Results:It showed that in Chinese herbal group Bcl-2,Bax and p53 expressions decreased remarkably,significantly different than that in other groups (P<0.05).Conclusion:Weiling Granules has the effect of and has better reversing function in proliferation of morbid cells before gastric cancer. |
| |
| Keywords: | Gastric precancerous lesion Weiling Granules Apoptosis |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
