多种指标联合检测非小细胞肺癌的诊断价值

目的：探讨血清中神经元特异性烯醇化酶（NSE）、癌胚抗原（CEA）、细胞角蛋白19片断（CYFRA21‐1）、乳酸脱氢酶（LDH）检测在非小细胞肺癌临床诊断中的价值。方法选择病理确诊的非小细胞肺癌患者86例作为研究对象，选取50例非肿瘤肺部感染患者及60例体检健康者血清作对照，采用Beckman全自动免疫分析系统检测患者血清中CEA、CYFRA21‐1水平，Roche411检测患者血清中NSE水平，Beckman全自动生化仪（AU5821）检测LDH水平，分析NSE、CEA、CYFRA21‐1、LDH水平与非小细胞肺癌临床特征之间的关系。结果（1）非小细胞肺癌患者血清中NSE、CEA、CYFRA21‐1、LDH水平明显高于非肿瘤肺部感染患者及健康者；（2）非小细胞肺癌组中NSE在未分型患者中水平明显高于鳞状细胞癌和腺癌患者，CYFRA21‐1在鳞状细胞癌中水平较高，CEA、LDH的水平差异不明显；（3）NSE、CEA、CYFRA21‐1联合检测阳性率高于NSE单独检测的阳性率。结论血清NSE、CEA、CYFRA21‐1水平联合检测有利于提高非小细胞肺癌的诊断率。

The diagnostic value of the combined detecting of NSE,CEA,CYFRA21-1,LDH in non-small-cell lung carcinoma

Objective To study the clinical diagnostic value of serum neuron-specific enolase （NSE） ,carcino‐embryonic antigen （CEA） ,cytokeratin 19 fragment （CYFRA21‐1） ,lactic dehydrogenase （LDH） in patients with non small cell lung cancer .Methods A total of 86 patients with non small cell lung carcinoma were selected as objects in this research ,50 patients with none tumor pulmonary infection and 40 healthy persons were selected into control group .CEA ,CYFRA21‐1 levels were detected by automatic immunoassay system Beckman ,the level of NSE were de‐tected by Roche 411 and LDH were detected by automatic biochemistry system .Analyzed the relationship between serum NSE ,CEA ,CYFRA21‐1 ,LDH levels and the clinical features of non small cell lung cancer patients .Results The serum NSE ,CEA ,CYFRA21‐1 ,LDH levels in non small cell lung carcinoma patients were significant higher than those in pulmonary infection patients and healthy persons .The NSE level in patients that subtype not defined was significant higher than the squamous -cell carcinoma patients and adenocarcinoma .CYFRA21‐1 was high in squamous-cell carcinoma ,no differences were found on the levels of CEA and LDH .The detection rate of the com‐bined detection of NSE ,CEA ,CYFRA21‐1 was higher than the single detection of NSE .Conclusion The combined detection of serum NSE ,CEA ,and CYFRA21‐1 could improve the diagnostic rate .