广州地区妊娠中晚期妇女AT-Ⅲ检测参考值范围调查

目的：对广州地区中晚期妊娠妇女抗凝血酶Ⅲ（AT-Ⅲ）参考值范围的调查，初步探讨AT-Ⅲ检测在妊娠妇女中的应用价值。方法选取健康妊娠妇女250例及同期体检的健康非妊娠妇女118例，将健康妊娠妇女按孕周分组：孕周14∽27周组设为中孕组，共124例，＞27周组设为！孕组，共126例。将上述各组按年龄再分为小于29岁组和大于或等于29岁组。收集所有入组人员抗凝静脉血1．8 mL，检测其血浆AT-Ⅲ水平，调查其相应的参考值范围。结果中孕组、晚孕组及健康对照组血浆AT-Ⅲ水平分别为99．0％（68．1％∽117．0％）、92．0％（71．1％∽112．0％）、103％（76．0％∽127．8％），差异有统计学意义（P＜0．05）。＜29岁的中孕组、晚孕组及健康对照组血浆 AT-Ⅲ水平分别为96．85％（71．20％∽116．85％）、93．60％（70．53％∽136．48％）、103．75％（80．68％∽139．48％），差异有统计学意义（P＜0．05）；≥29岁的中孕组、晚孕组及健康对照组血浆AT-Ⅲ水平分别为95．47％（77．40％∽113．54％）、92．40％（69．20％∽113．00％）、102．08％（75．20％∽123．80％），差异有统计学意义（P＜0．05）。妊娠妇女AT-Ⅲ水平在不同孕期组间差异有统计学意义（P＜0．05），应制订不同的参考范围，而同一孕期内不同年龄段妊娠妇女AT-Ⅲ水平差异无统计学意义（P＞0．05），制订参考范围时可不考虑年龄因素。结论该研究为广州地区中晚期妊娠妇女人群AT-Ⅲ的参考值范围制订提供了一定的参考依据。

Survey of reference value ranges for AT-III of women in second and third trimesters in Guangzhou

Objective To disscuss the significance of detection of plasma antithrombin-Ⅲ（AT-Ⅲ）in pregnant women,through investigating the reference value ranges for AT-Ⅲ of women in middle term and late pregnancy in Guangzhou.Methods 250 healthy pregnant women and 118 healthy non-pregnant women（control group）were selected as subjects.According the gestation-al weeks,250 healthy pregnant women were divided into two groups：second trimester group（124 cases,14-27 weeks gestation） and third trimester group （126 cases,〉27 weeks gestation）.The two experimental groups were divided into two age groups：〈29 age group and ≥29 age group.1.8 mL anticoagulant venous blood was collected from each subjects and used for the detection of AT-Ⅲ,and the reference value ranges were investigated.Results The levels of AT-Ⅲ in second trimester group,third trimester group and control group were 99.0%（68.1%-117.0%）,92.0%（71.1%-112.0%）and 103%（76.0%-127.8%）,with signifi-cant difference（P〈0.05）.The AT-Ⅲ levels of women under-29-years old in second trimester group,third trimester group and control group were 96.85%（71.20%-116.85%）,93.60%（70.53%-136.48%）and 103.75%（80.68%-139.48%）,with sig-nificant difference（P〈0.05）.Meanwhile,the AT-Ⅲ levels of women aged 29 years and above in second trimester group,third tri-mester group and control group were 95.47%（77.40%-113.54%）,92.40%（69.20%-113.00%）and 102.08%（75.20%-123.80%）,also with significant difference（P〈0.05）.The AT-Ⅲ levels were significantly different between two trismester groups （P〈0.05）,but were not different among age groups（P〉0.05）.So the gestational factors should be considered when make the AT-Ⅲ reference range,and regardless of age.Conclusion This study provides reference basis for the establishment of AT-Ⅲ refer-ence values of women in second and third trismesters in Guangzhou.