AFU联合AFP在原发性肝癌诊断及术后治疗中的临床价值

目的：探讨血清α-L-岩藻糖苷酶（AFU）和血清甲胎蛋白（AFP）联合检测对原发性肝癌（PHC）的临床诊断价值，以及探讨AFU在PHC术后治疗监测中的作用。方法收集2013年1～5月PHC患者93例（其中术前40例，术后53例），肝硬化患者15例，病毒性肝炎患者15例和健康体检者15例（对照组），分别对各组患者及体检者进行血清AFP 和AFU 同步测定，并对PHC患者进行术前、术后AFP和AFU检测。结果 PHC患者术前血清AFU 水平均明显高于肝硬化组、病毒性肝炎组和对照组（P＜0．01）；PHC患者术后 AFU、AFP 水平均明显低于术前（P＜0．05）；PHC 患者术后 AFU、AFP 水平均高于对照组（P＜0．01）；AFU、AFP单独检测，以及AFU联合AFP检测的受试者工作特征曲线（ROC）下面积分别为0．727、0．798、0．858。结论AFU联合AFP检测能提高PHC诊断的敏感性和特异性；AFU可作为PHC术后治疗监测，病情转归及预后的有效指标。

The clinical value of AFU combined with AFP in diagnosis of hepatocellular carcinoma and the postoperative treatment

Objective To explore the diagnostic value of serum alpha fetoprotein （AFP） and alpha-L-fucosidase（AFU） in the primary liver cancer and to explore the significance of AFU in monitoring liver cancer after surgery treatment. Methods 93 patients with primary liver cancer（including 40 cases before surgery,53 cases after surgical treatment）, 15 patients with liver cirrhosis, 15 cases of viral hepatitis and 15 cases of healthy subjects were collected from January to May of 2013. The levels of serum AFP and AFU in primary liver cancer patients（before and after treatment）and healthy subjects were detected. Results The level of serum AFU in primary liver cancer patients was significantly higher than cirrhosis group, healthy control group and viral hepatitis group （P〈0.01）. After surgery treatment,the levels of AFU and AFP in liver cancer patients were obviously lower than before surgery （P〈0. 051 ,The level of AFP was obviously higher than the healthy control group（P〈0. 011. The areas under the curve （AUC） of AFU,AFP and AFU-AFP combination detection were 0. 727,0. 798 and 0. 858 respectively. Conclusion AFU AFP combination detection can improve sensibility and specificity in diagnosing primary liver cancer and the serum AFU can use an effective indicator to monitor liver cancer postoperative treatment and to predict disease outcome.