Translational Regulation as a Novel Mechanism for the Development of Cellular Drug Resistance |
| |
| Authors: | John C Schmitz Jun Liu Xiukun Lin Tian-min Chen Wu Yan Ningwen Tai Ashwin Gollerkeri Edward Chu |
| |
| Institution: | (1) Department of Medicine and Pharmacology, Yale Cancer Center, Yale University School of Medicine and VA CT Cancer Center, VA CT Healthcare System, New Haven, CT, USA |
| |
| Abstract: | Cellular drug resistance is one of the principal obstacles to the clinical efficacy of cancer chemotherapy. In this review, we describe the potential role for translational regulation as a novel mechanism for modulating chemosensitivity. The evidence for the translational control of thymidylate synthase, dihydrofolate reductase, and p53 will be presented, as will experimental data showing how disruptions in this important regulatory process can lead to the rapid emergence of cellular drug resistance. |
| |
| Keywords: | thymidylate synthase dihydrofolate reductase p53 translational regulation drug resistance |
| 本文献已被 PubMed SpringerLink 等数据库收录！ |
|
