| E钙黏着素与波形蛋白在膀胱癌中的表达及意义 |
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| 引用本文： | 董大海,赵军,孙立江,张桂铭. E钙黏着素与波形蛋白在膀胱癌中的表达及意义[J]. 现代泌尿外科杂志, 2010, 15(1): 22-24 |
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| 作者姓名： | 董大海 赵军 孙立江 张桂铭 |
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| 作者单位： | 青岛大学医学院附属医院泌尿外科,山东青岛,266003 |
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| 摘 要： | 目的检测E钙黏着素（E—cadherin）和波形蛋白（Vimentin）在膀胱癌组织中表达及意义：方法采用免疫组织化学技术检测60例膀胱移行细胞癌组织中E—cadherin和Vimentin的表达，分析二者的相关性及其与膀胱癌病理分级的关系。结果E—cadherin和Vimentin在不同病理分级的膀胱癌组织中的表达差异有统计学意义（P〈o．01），E-cadherin异常表达与Vimentin阳性表达成正相关（r=0．330，P〈20．05）。结论初步证实在膀胱癌的发生、发展中可能存在上皮间质转化（EMT）现象；联合检测E-cadherin及Vimentin对判断膀胱癌患者的预后具有一定的临床价值。
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| 关 键 词： | 膀胱癌 E钙黏着素 波形蛋白 免疫组织化学 |
The expression and significance of E-cadherin and Vimentin in transitional cell carcinoma of the bladder |
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| DONG Da-hai,ZHAO Jun,SUN Li-jiang,ZHANG Gui-ming. The expression and significance of E-cadherin and Vimentin in transitional cell carcinoma of the bladder[J]. Journal of MOdern Urology, 2010, 15(1): 22-24 |
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| Authors: | DONG Da-hai ZHAO Jun SUN Li-jiang ZHANG Gui-ming |
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| Affiliation: | Department of Urology/a>;Affiliated Hospital of Medical College of Qingdao University/a>;Qingdao 266003/a>;China |
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| Abstract: | Objective To detect the expression of E-cadherin and Vimentin and to discuss their significance for prognosis.Methods The expression of E-cadherin and Vimentin in 60 specimens of transitional cell carcinoma of the bladder was detected by SP immunohistochemistry.Results The expressions of both E-cadherin and Vimentin in three differentiated grades of transitional cell carcinoma of the bladder were statistically significant(both P<0.01).There was a positive correlation between the abnormal expression of E-cad... |
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| Keywords: | bladder cancer E-cadherin Vimentin immunohistochemistry |
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