冬寒菜类胡萝卜素对二乙基亚硝胺诱发大鼠恶性肿瘤的抑制作用

流行病学及部分实验研究结果表明一些类胡萝卜素成分不经转化为维生素A就可发挥抑癌作用。本实验研究发现补充冬寒菜类胡萝卜素(42.27mg胡萝卜素/Kg饲料)能有效地抑制二乙基亚硝胺诱发大鼠肝细胞癌及肺转移癌的发生,并可有效地延长肿瘤的潜伏期及荷瘤动物的平均寿命。而补充丙酮-石油醚混合液提尽全部色素的冬寒菜提取后干粉无类似作用。

THE INHIBITORY EFFECT OF THE VEGETABLE CAROTENOIDS ON THE DEVELOPMENT OF MALIGNANT TUMORS INDUCED BY DIETHYLNITROSAMINE IN RATS

The chemoprevention of Malva crispa L. carotenoids on DENA-inducedmalignant tumors was studied in Wistar rats. Groups of rats were fed a semisynthetic diet supplemented with either dried Malva crispa L. powder (containing 878.19 mg carotene/kg diet)or acetone-petroleum ether extracted anddried Malva crispa L. powder (containing 2.08 mg caroteue/kg diet). Malignant tumors were induced by gavage of DENA dissolved in double distilledwater (DDW).The data showed that supplementation of Malva crispa L. carotenoidssignificantly reduced the incidence of hepatoma or lung metastatic carcinomaand the severity of preneoplastic changes. The vegetable carotenoids also postponed the occurrence of malignant tumors and prolonged the longevity of therats treated with DENA. However, acetone-petroleum ether extracted Malvacrispa L. Powder supplementation did not affect the tumor of the liver or lung. These results indicate that vegetable carotenoids at the dosageof 42.27 mg carotene/kg diet(as in this study)may exert bettet chemopreventire action.