围绝经女性糖尿病微血管病变与血脂异常的相关性研究

目的：：探讨血脂异常与围绝经期女性糖尿病微血管病变发生的相关性。方法：围绝经期女性2型糖尿病患者120例，依据有无糖尿病微血管病变分为病例组和对照组，每组60例。分别检测两组的血脂、血压、空腹血糖(FBG)和糖化血红蛋白(HbA1C)等指标。结果：病例组患者的病程、FBG、低密度脂蛋白胆固醇(LDL-C)、HbA1C、收缩压明显高于对照组，高密度脂蛋白胆固醇明显低于对照组(P＜0.05)；两组年龄、甘油三酯、总胆固醇、体重指数、舒张压比较差异无统计学意义(P＞0.05)。Logistic回归分析显示，病程、FBG、LDL-C、HbA1C是糖尿病微血管病变的独立危险因素。结论：LDL-C升高和高血糖与围绝经期女性2型糖尿病微血管病变的发生密切相关。

RELATIONSHIPS BETWEEN DYSLIPIDEMIA AND DIABETIC MICROANGIOPATHY IN PERIMENOPAUSAL WOMEN WITH TYPE 2 DIABETES MELLITUS

[ABSTRACT]Objective: To investigate the relationships between dyslipidemia and diabetic microangiopathy in perimenopausal women with type 2 diabetes mellitus.Methods: 120 perimenopausal women with type 2 diabetes mellitus were divided into case group (60 cases) and control group (60 cases) according to diabetic microangiopathy. The blood lipid, blood pressure, fasting blood-glucose (FBG) and glycosylated hemoglobin (HbA1C) were respectively detected.Results:The course of disease, FBG, low density lipoprotein cholesterin (LDL-C), HbA1C and systolic blood pressure of patients in case group were obviously higher than that of patients in control group (P<0.05); high density lipoprotein cholesterin was obviously lower (P<0.05). There had no statistical signiifcance between age, triglyceride, total cholesterol, body mass index and diastolic blood pressure of patients in case group and control group (P>0.05). Logistic regression analyses showed that course of disease, FBG, LDL-C, and HbA1C are independent risk factors of diabetic microangiopathy.Conclusions: High LDL-C and hyperglycemia are closely related to diabetic microangiopathy in perimenopausal women with type 2 diabetes mellitus.