抑郁症患者下丘脑-垂体-肾上腺轴功能与自杀行为

目的：了解抑郁症患者自杀行为与下丘脑－垂体－肾上腺（ＨＰＡ）轴的关系。方法：对２５例抑郁症患者行地塞米松抑制试验（ＤＳＴ），其中伴有自杀行为的１２例，不伴自杀行为的１３例，并进行为期１年的随访。结果：自杀组和无自且的ＤＳＴ脱抑制率无明显差异。血有皮质醇水平与汉密尔顿抑郁量（ＨＡＭＤ）评分有明显相关。随访期间所有受试者均未发生新的自杀行为。结论：抑随症患者的ＨＰＡ轴功能失调与自杀行为有关，但并不增加

Hypothalamic-pituitary-adrenal axis function and suicidal behavior in depression

Objective:To study the relationship between hypopituitaryadrenocortical (HPA) function and suicidal behavior in depression. Method:Dexamethasone suppression test (DST) was peformed in 25 depression patients including 12 patients with suicidal behavior,13 patients without suicidal behavior.A year of follow up was carried. Results:After the DST,the patients with suicidal behavior had no significant difference in the rate of non suppressors from the patients without suicidal behavior.The significant correlation between serum cortiso levels and the HAMD was found.The study did not find any reattempt suicidal behavior during the follow up in all patients. Conclusion:These results suggested the dysregulation of the HPA axis might be associated with suicidal behavior in depression patients,it did not increase the risk of suicide.Therefore,the DST should not be regarded as a predictor of suicidal behavior in depression patients.