炎性和非炎性疾病患者外周血25（OH）D水平与超敏C反应蛋白浓度的相关性

目的探讨炎性和非炎性疾病患者外周血25羟维生素D［25（OH）D］水平与超敏C反应蛋白（hs-CRP）浓度的相关性。 方法回顾2017年9~11月已确诊的门诊或住院患者共281例，按是否存在炎性疾病分为炎性组130例和非炎性组151例，采用电化学发光法检测外周血25（OH）D水平，用散射比浊法检测外周血hs-CRP浓度，采用的Pearson相关分析分析25（OH）D水平与hs-CRP浓度的相关性。 结果炎性疾病组25（OH）D水平与hs-CRP浓度呈负相关（r=-0.780，P<0.001）。非炎性疾病组25（OH）D水平与hs-CRP浓度呈负相关（r=-0.636，P<0.001）。 结论炎性组与非炎性组患者外周血25（OH）D水平与hs-CRP浓度均呈负相关，炎性组的相关性高于非炎性组，其机制有待进一步探讨。

Association between peripheral blood levels of 25(OH)D and hypersensitive C-reactive protein in patients with inflammatory and non-inflammatory diseases

ObjectiveTo investigate the correlation between peripheral blood levels of 25-hydroxyvitamin D [25(OH)D] and hypersensitive C-reactive protein (hs-CRP) in patients with inflammatory and non-inflammatory diseases. MethodsA total of 281 patients (130 patients with inflammatory disease and 151 cases with non-inflammatory disease) were involved in this study between September 2017 and November 2017. The levels of 25(OH)D and hs-CRP in peripheral blood were detected by electrochemiluminescence and turbidimetry, respectively. ResultsThe levels of 25(OH)D in the inflammatory disease group were significantly negatively correlated with those of hs-CRP (r=-0.780, P<0.001). In the non-inflammatory disease group, the 25(OH)D levels and hs-CRP concentrations had a weaker negative association (r=-0.636, P<0.001). ConclusionPeripheral blood levels of 25(OH)D are negatively associated with hs-CRP not only in patients with inflammatory disease but also in non-inflammatory populations. The correlation in the inflammatory group is significantly higher than that in the non-inflammatory group.