Epithelial cells as immune effector cells: The role of CD40 |
| |
| Authors: | Kari Dugger Thomas W. Lowder Torry A. Tucker Lisa M. Schwiebert |
| |
| Affiliation: | aDepartment of Physiology and Biophysics, University of Alabama at Birmingham, United States;bTexas Lung Injury Institute, University of Texas Health Science Center at Tyler, United States |
| |
| Abstract: | Through the expression of inflammatory mediators and immune-related molecules, epithelial cells function as immune effector cells in a wide variety of tissues; the expression of the CD40 receptor on these cells contributes this role. Engagement of CD40 activates epithelial cells and results in their release of pro- and anti-inflammatory mediators as well as pro-fibrotic molecules. As such, epithelial CD40 has been implicated in the pathogenesis of inflammatory disorders, generation of self-tolerance, and rejection of allografts. |
| |
| Keywords: | smCaps" >CD40 Epithelia |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
