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Epithelial cells as immune effector cells: The role of CD40
Authors:Kari Dugger   Thomas W. Lowder   Torry A. Tucker  Lisa M. Schwiebert  
Affiliation:aDepartment of Physiology and Biophysics, University of Alabama at Birmingham, United States;bTexas Lung Injury Institute, University of Texas Health Science Center at Tyler, United States
Abstract:Through the expression of inflammatory mediators and immune-related molecules, epithelial cells function as immune effector cells in a wide variety of tissues; the expression of the CD40 receptor on these cells contributes this role. Engagement of CD40 activates epithelial cells and results in their release of pro- and anti-inflammatory mediators as well as pro-fibrotic molecules. As such, epithelial CD40 has been implicated in the pathogenesis of inflammatory disorders, generation of self-tolerance, and rejection of allografts.
Keywords:  smCaps"  >CD40   Epithelia
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