| 胆囊良恶性病变组织中P-504S和P63表达及临床病理意义 |
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| 引用本文： | 吕芳,杨竹林,苗雄鹰,杨乐平,罗鑫.胆囊良恶性病变组织中P-504S和P63表达及临床病理意义[J].临床肝胆病杂志,2009,25(3):199-201. |
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| 作者姓名： | 吕芳 杨竹林 苗雄鹰 杨乐平 罗鑫 |
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| 作者单位： | 中南大学湘雅二医院肝胆疾病研究室,湖南,长沙,410011 |
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| 摘 要： | 目的研究胆囊腺癌、癌旁组织和慢性胆囊炎组织中的α-甲酰基辅酶A消旋酶（P504S）和P63蛋白表达及其临床意义。方法108例胆囊腺癌、46例癌旁组织和35例慢性胆囊炎手术切除标本常规制作石蜡包埋切片,P504S和P36染色方法为EnVision^TM免疫组化法。结果胆囊腺癌P504S和P63阳性率（51.9%,43.5%）及其评分（2.13±1.88,1.98±1.73）明显高于癌旁组织阳性率（17.9%,10.9%）及其评分（0.72±1.24,0.61±1.39）和慢性胆囊炎阳性率（14.3%,6.0%）及其评分（0.59±1.34,0.32±1.22）（P〈0.01）;腺瘤癌变或高分化腺癌、无淋巴结转移及未侵犯周围组织器官病例P504S表达阳性率及其评分明显低于低分化腺癌、淋巴结转移及侵犯周围组织器官病例（P〈0.05,或P〈0.01）;无淋巴结转移病例P63表达阳性率及其评分明显低于转移病例（P〈0.05）。结论P504S和P63表达与胆囊腺癌发生发展有密切关系,P504S可能是反映胆囊腺癌生物学行为和预后的重要生物学指标。
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| 关 键 词： | 胆囊肿瘤 慢性胆囊炎 α-甲酰基-辅酶A消旋酶 P63 免疫组织化学 |
Expression of P504S and P63 and their clinicopathological significances in the benign and malignant lesions of gallbladder. |
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| LV Fang,YANG Zhu-lin,MIAO Xiong-ying,et al..Expression of P504S and P63 and their clinicopathological significances in the benign and malignant lesions of gallbladder.[J].Chinese Journal of Clinical Hepatology,2009,25(3):199-201. |
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| Authors: | LV Fang YANG Zhu-lin MIAO Xiong-ying |
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| Institution: | Research Laboratory of Hepatobiliary Diseases;The Second Xiangya Hospital of Central South University;Changsha;Hunan 410011;China |
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| Abstract: | Objective To study the expressive levels of P504S and P63 and detect their clinicopathological significances in gallbladder adenocarcinoma,pericancerous tissues and chronic cholecystitis.Methods Immunohistochemical method of EnVisionTM was used for assaying the expressive levels of P504S and P63 in routinely paraffin-embedded sections of the specimens from patients with gallbladder adenocarcinoma(n=108),pericancerous tissues(n=46) and chronic cholecystitis(n=35).Results The positive rates and scores of P504... |
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| Keywords: | P63 gallbladder neoplasms chornic cholecystitis P63 immunohistochemistry |
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