| 吲哚美辛-β-环糊精包合物的制备、鉴定及溶出度的测定 |
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| 引用本文： | 王维贤,石庭森,缪振春,高立军,张涛,林裔珍. 吲哚美辛-β-环糊精包合物的制备、鉴定及溶出度的测定[J]. 中国药学杂志, 1994, 29(5): 279-282 |
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| 作者姓名： | 王维贤 石庭森 缪振春 高立军 张涛 林裔珍 |
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| 作者单位： | 北京军事医学科学院毒物药物研究所，北京橡胶工业设计研究院 |
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| 摘 要： | 本文选用共沉淀法制备了吲哚美辛－β－环糊精包合物（简称包合物）。经X－射线衍射法、差热分析法以及NMR法进行鉴定，证明吲哚美辛与β－环糊精（简称β－CD）确已形成包合物，吲哚美辛的苯环部分被个β－CD包合；含量测定证明主、客分子比为1∶1；经溶出度测定，包合物可明显提高吲哚美辛的溶解度及溶解速度。
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| 关 键 词： | 吲哚美辛 β－环糊精 包合物 溶出度 |
| 收稿时间： | 1993-02-09; |
Complex of indomethacin-β-CD preparation,identification and solubili-ty determination |
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| WANG Wei-xian,SHI Ting-sen,MIAN Zhen-chun,GAO Li-jun,ZHANG Tao,LIN Yi-zhen. Complex of indomethacin-β-CD preparation,identification and solubili-ty determination[J]. Chinese Pharmaceutical Journal, 1994, 29(5): 279-282 |
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| Authors: | WANG Wei-xian SHI Ting-sen MIAN Zhen-chun GAO Li-jun ZHANG Tao LIN Yi-zhen |
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| Affiliation: | Institute of Pharmacology and Toxicology;Academy of Military Medical Sciences;Beijing 100850 |
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| Abstract: | The complex of indomethacin-β-CD was produced by co-precipitating method.Structure examination of X-ray diffraction,differential scanning calorimetric method and nuclearmagnetic resonance, proved that the benzyl moiety of indomythacin was enveloped by β-CD.Quantitative analysis demmonstrated that the molecular ratio of indomethacin to β-CD in thecomplex was 1∶1,and that the solubility and dissolution rate of indomethacin were promotedwhen the drug was wrapped by β-CD. |
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| Keywords: | indomethacin β-cyclodextrian complex solubility |
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