| 葛根黄豆苷元衍生物的合成及理化性质研究 |
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| 引用本文： | 姜铁夫,康万军,杜妙,佟志清. 葛根黄豆苷元衍生物的合成及理化性质研究[J]. 解放军药学学报, 2006, 22(3): 228-230 |
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| 作者姓名： | 姜铁夫 康万军 杜妙 佟志清 |
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| 作者单位： | 中国人民解放军第463医院,辽宁,沈阳,110042;中国人民解放军广州军区广州总医院,药学部,广东,广州,510010 |
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| 摘 要： | 目的为了提高葛根黄豆苷元溶解度,本文合成了一系列葛根黄豆苷元衍生物,并筛选了葛根4’-氧代乙酸7-羟乙氧基-黄豆苷元(DZ18)。方法本实验采用半合成的方法,以葛根黄豆苷元为母体,在7位、4’位导入基团生成黄豆苷元双置换体。结果新合成的化合物DZ18溶解度较葛根黄豆苷元有提高。结论DZ18溶解度有提高,符合实验设计要求。
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| 关 键 词： | 葛根黄豆苷元 DZ18 合成 评价 |
| 文章编号： | 1008-9926（2006）03-0228-03 |
| 收稿时间： | 2005-05-31 |
| 修稿时间： | 2006-04-06 |
Synthesis and Study of Daidzeiderivative DZ18 |
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| JIANG Tie-Fu,KANG Wan-Jun,DU Miao,TONG Zhi-Qing. Synthesis and Study of Daidzeiderivative DZ18[J]. Pharmaceutical Journal of Chinese People's Liberation Army, 2006, 22(3): 228-230 |
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| Authors: | JIANG Tie-Fu KANG Wan-Jun DU Miao TONG Zhi-Qing |
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| Abstract: | Aim To improve the solubility of daidzein,a series of daidzein derivatives has been synthesized,and DZ18 was screened.Methods The D-isplacement was made in 7 and 4' baseplace of Daidzein by semi-synthetic method.Results The solubility of new Compounds(DZ18) has been improved.Conclusion The solubility has been improved,and DZ18 is up to the standard. |
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| Keywords: | DZ18 |
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