Artemisinin therapeutic efficacy in the experimental model of multiple sclerosis |
| |
| Authors: | Mohammad Reza Khakzad Vahid Ariabod Iman Farahani |
| |
| Affiliation: | 1. Innovative Medical Research Center, Department of Immunology, Mashhad Branch, Islamic Azad University, Mashhad, Iran;2. Allergy Research Center, Mashhad, University of Medical Sciences, Mashhad, Iran;3. Department of Pathology, Mashhad Branch, Islamic Azad University, Mashhad, Iran;4. Molecular and Medicine Research Center, Arak University of Medical Sciences, Arak, Iran;5. Department of Microbiology and Immunology, School of Medicine, Arak University of Medical Sciences, Arak, Iran |
| |
| Abstract: | Context: The immune system through T-helper 1 (Th1) and Th17 cells play a critical role in the pathogenesis of experimental autoimmune encephalomyelitis (EAE), whereas the Th2 responses inhibit myelin degeneration. Artemisinin, as an anti-malaria as its agent, has been used widely in the treatment of malaria, shifts the lymphocyte responses from Th1 to Th2.Objective: In this study, we have investigated the therapeutic effects of artemisinin on the EAE treatment.Materials and methods: EAE was induced in the inbred C57BL6 mice. High and low doses of prednisolone and artemisinin were injected daily with the control and test groups, respectively. The spleen and the brain of the mice were removed and used for ELISA and histological studies.Results: The mean weight of mice was significantly (p value?p value p value?p value?Conclusions: Since, artemisinin can shift the immune responses from Th1 to Th2, therefore, it can be helpful in the treatment of MS after more investigation. |
| |
| Keywords: | Artemisinin autoimmune diseases cytokines experimental autoimmune encephalomyelitis multiple sclerosis |
|
|
