Photodynamic therapy of C3H tumours in mice: Effect of drug/light dose fractionation and misonidazole |
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Authors: | Jan F Evensen Johan Moan |
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Institution: | (1) Institute for Cancer Research, Department of Biophysics, The Norwegian Radium Hospital, Montebello, 0310 Oslo 3, Norway |
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Abstract: | C3H mammary carcinomas transplanted to the feet of mice were treated with haematoporphyrin derivative (HPD) or Photofrin II(PII)
and laser light at 630 nm. While fluence rates lower than 100 mW cm−2 gave minimal hyperthermic effects, a slight but significant growth delay was observed in unsensitized tumours exposed to
a fluence rate of 150 mW cm−2 which induced tumour temperatures in the range 40–50°C. Different modes of fractionation of the light fluence and of the
HPD dose were tested but were found to give poorer rather than better results than the application of a single light exposure
24 h after intraperitoneal injection of HPD. Different PII doses were applied together with different light fluences, keeping
the product of the drug dose and light fluence constant. In the dose range 6.25–50 mg/kg body weight the resulting effect
on tumours was constant, allowing for a slight effect of hyperthermia at the highest light fluences, and possibly a photodegradation
of PII. Misonidazole given before photodynamic treatment (PDT) slightly reduced the effect of PDT on the tumour growth. When
given after PDT, however, misonidazole improved the therapeutic results significantly. |
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Keywords: | Photodynamic therapy Hyperthermia Fractiontation Misonidazole C3H tumour |
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