Effects of simvastatin on ion channel currents in ventricular myocytes from rabbit with acute myocardial infarction |
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| Authors: | Chao Ding Li Yang Huixiao Chen Junxia Li Yuying Zhao Jie Li Jie Wang Xianghua Fu |
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| Affiliation: | Chao Ding~1 Xianghua Fu~2 Li Yang~1 Huixiao Chen~1 Junxia Li~1 Yuying Zhao~1 Jie Li~1 Jie Wang~1 1 Department of Cardiology,Bethune International Peace Hospital of Chinese PLA,Shijiazhuang Hebei 050082 China 2 Department of Cardiology,The Second Hospital,Hebei Medical University,Shijiazhuang Hebei 050000,China |
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| Abstract: | Objective To investigate the effects of simvastatin on membrane ionic currents in left ventricular myocytes after acute myocardial infarction (AMI,so as to explore the ionic mechanism of statin treatment for antiarrhythmia.Methods Fourty-five New Zeland rabbits were randomly divided into three groups:AMI group,simvastatin intervention group (statin group) and sham-operated control group (CON).Rabbits were infarcted by ligation of the left anterior descending coronary artery after administration of oral simv... |
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| Keywords: | simvastatin myocardial infarction ionic channels patch-clamp rabbit |
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