基础窦卵泡数预测体外授精超排卵周期卵巢低反应的Meta分析

 目的 探讨在体外授精(in-vitro fertilization,IVF)超排卵周期,基础窦卵泡数(basisantral follicle count, bAFC)预测卵巢低反应性的价值。方法 收集国内外有关bAFC与IVF超排卵周期卵巢低反应的相关研究,符合纳入与排除标准的相关文献共11篇,涉及患者11425例,采用RevMan5.2软件对纳入的文献进行meta分析。结果 通过对纳入的11项研究进行meta分析显示,bAFC直接影响获卵数和促性腺激素(Gn)使用量(支),bAFC越多,获卵数越多,促性腺激素(Gn)使用量越少,差异有统计学意义。获卵数(SMD合并-0.87,95%CI:-1.22--0.52;Z=4.84,P<0.00001);促性腺激素(Gn)使用量(支)(SMD合并0.68,95%CI:0.21-1.15;Z=2.83,P=0.005)。结论 bAFC对IVF超排卵周期卵巢低反应性具有预测价值,可作为独立监测指标。

Meta-analysis of poor ovarian response to ovarian hyperstimulation during IVF cycles predicted with bAFC

Objective To conduct meta-analysis of bAFC prediction of poor ovarian response to ovarian hyperstimulation during IVF cycles.Methods According to inclusion and exclusion criteria,data on related studies of antral follicle count and poor ovarian response was collected via electronic databases.A total of eleven pieces of literature involving 11425 patients were included and meta-analysis was made with RevMan5.2 software.Results Eleven studies were included in the meta-analysis.The results showed that along with the increase of bAFC,the number of oocytes obtained became larger.bAFC had a direct effect on the number of oocytes retrieved and the amount of gonadotropin (Gn) used.Conclusions Meta-analysis suggests that bAFC can serve both as a predictor of poor ovarian response to ovarian hyperstimulation during IVF cycles and as an independent indicator of surveillance.