急性心肌梗死血栓调节蛋白改变与超敏肌钙蛋白T的相关性

 目的 观察急性心肌梗死(acute myocardial infarction,AMI)患者血栓调节蛋白(thrombomodulin, TM)的变化与超敏肌钙蛋白T(hypersensitivity troponin T, hsTnT)的相关性。方法 采用病例对照研究方法,选择符合入选标准的AMI患者(AMI组)和健康人(对照组)各30例(名),采集血液标本,采用酶联免疫检测法检测TM的浓度,利用SPSS统计软件进行数据分析。结果 AMI组TM、肌酐(简称Cr)及TM/Cr均大于对照组,差异有统计学意义(P<0.05);TM与hsTnT呈正相关(r=0.524, P<0.05),TM/Cr与hsTnT呈正相关(r=0.725,P<0.05)。结论 AMI患者TM明显增加,TM与hsTnT呈正相关,且TM/Cr可做为诊断急性心肌梗死的指标。

Changes of trombomodulin and correlations with hsTNTin patients with acute myocardial infarction

Objective To study the variation of thrombomodulin (TM) and the correlations with the hypersensitivity troponin T("hsTnT"for short) in patients with acute myocardial infarction (AMI).Methods The case-control method was used to recruit 30 subjects with AMI and another 30 healthy people as the control group.Enzyme-linked immunoassays were used to detect TM and SPSS was used for data analysis.The correlations between TM and hsTnT were studied.Results TM,creatinine and TM/creatinine ratio were increased in patients with AMI (P ＜ 0.05),and TM and TM/Cr ratio were positively correlated with hsTnT (r =0.524,P ＜ 0.05;r =0.725,P ＜ 0.05).Conclusions TM is increased in patients with AMI,and TM/Cr ratio can be used as a molecular marker ofacute myocardial infarction.