急性冠状动脉综合征患者ALDH2基因型和红细胞体积分布宽度变化的关系

 目的 分析我国急性冠状动脉综合征(acute coronary syndrome, ACS)患者乙醛脱氢酶2(ALDH2)基因多态性与红细胞体积分布宽度(RDW)变化的关系。方法 收集128例ACS患者临床基线数据,按不同RDW区间进行分类,对患者相关的临床数据及ALDH2基因型分布频率,以及等位基因分布频率进行比较,并分析ALDH2基因多态性及冠状动脉病变严重程度与RDW水平的相关性。结果 将RDW按四分位数分为4组,不同RDW组间ACS患者其超敏C反应蛋白Q1~Q4组分别为:(4.12±0.77)、(5.89±0.89)、(5.01±0.76)、(7.66±0.95)mg/L和血肌酐Q1~Q4组分别为:(70.3±19)、(76.8±21)、(74.1±23)、(86.5±24)μmol/L,差异均有统计学意义(P<0.05)。4组间ALDH基因型分布差异有统计学意义(P<0.05),G和A等位基因分布的频率差异也有统计学意义(P<0.05)。ALDH基因型与Gensini积分呈显著相关(r=-0.154, P<0.05),ALDH2基因型多态性对RDW大小存在显著性影响(r=-0.386,P<0.05)。结论 我国ACS患者中ALDH2基因多态性与RDW存在密切的相关性。

Relationships between genotype of ALDH2 and red blood cell distribution width in patients of acute coronary syndrome

Objective To analyze the relationship between red blood cell distribution wdth (RDW) and aldehyde dehydrogenase-2 polymorphism in acute coronary syndrome in China.Methods The baseline clinical data of 128 ACS patients were collected and evaluated.Aldehyde dehydrogenase-2 genotype and the distribution frequency of allele in different RDW groups were analyzed.Correlation analysis was made of ALDH gene polymorphism,the level of coronary artery disease and RDW.Results There was significant difference in high sensitive C reaction protein between different RDW groups (P ＜ 0.05).hs-CRP was (4.12-± 0.77) mg/L,(5.89 ± 0.89) mg/L,(5.01 ±0.76)mg/L,and (7.66 ±0.95) mg/L respectively in groups Q1 to Q4 while CERA was (70.3 ± 19.0) μmol/L,(76.8 ±21.0)μmol/L,(74.1 ±23.0) μmol/L,and (86.5 ±24.0 μmol/L) in plasma creatinine in groups Q1-Q4.There was statistically significant difference between the four groups in ALDH gene type,as in the distribution frequency of allele.There were significant positive correlations between Gensini score and RDW(r =-0.154,P ＜ 0.05 ALDH genotype had a significant effect on RDW (r =-0.386,P ＜ 0.05).Conclusions There are close correlations between ALDH genotype and RDW in ACS patients in China.