| Abstract: | Summary Over a period of seven years the anterior descending branch of the left coronary artery was acutely ligated in a total of 93 dogs. Two control series, 1963/1964 and 1969/1970, on 11 and 13 dogs respectively, produced essentially identical survival rates of 9.1% and 7.7% despite variations in the experimental team. Two experimental series performed at the same time with Intensain pretreatment show essentially the same survival rate (62.2%,p<0,05 and 66.7%,p<0.01, respectively.After pretreatment with Persantin the survival rate of 84.7% is likewise significantly higher than in the control animals (p<0.001). After prolonged administration of Carduben, 42.9% of the experimental animals survived coronary occlusion (p<0.05).If young animals of the age of 9 to 12 months are used in the control series, the survival rate of 58.3% is clearly higher than with adult ones (p<0.01). If young animals receive prophylactically Pteridinol (RE 102), the survival rate is increased after acute occlusion of the anterior descending artery to 91.1% (p<0.05). The higher survival rate in young animals may be explained by an improved collateral circulation of the myocardium.The good reproducibility of survical rates following acute coronary occlusion over several years with both controls and treated dogs proves the significance of comparative studies between treated and untreated animals. The experimental conditions, age and living conditions, however, must be comparable. |
