冠心病患者血脂异常及炎症反应与颈动脉斑块形成关系的初探

目的探讨冠心病患者血脂异常及炎症反应与颈动脉斑块形成的关系。方法选择2009-05～2013-04在该院住院治疗的132例冠心病患者，彩超检查颈动脉显示伴有颈动脉斑块形成93例（观察组），不伴有颈动脉斑块39例（对照组）。均常规检测总胆固醇（TC）、低密度胆固醇（LDL-C）、甘油三酯（TG）、高密度胆固醇（HDL—C）和超敏C反应蛋白（hs-CRP）。结果观察组血清TC和LDL—C均高于对照组（P〈0．05或〈0．01），而两组的hs—CRP、TG及HDL-c差异无统计学意义（P均〉0．05）。结论冠心病患者中高TC和高LDL-C可能与颈动脉斑块形成有关，而hs-CRP与颈动脉斑块形成无明显关联。

The relationship between abnormal blood lipid and inflammatory reaction and carotid atherosclerotic plaque formation in patients with coronary heart disease

Objective To investigate whether or not the abnormal blood lipid and inflammatory reaction as- sociated with carotid atherosclerotic plaque formation in patients with coronary heart disease. Methods One hundred and thirty-two coronary heart disease patients with or without carotid atherosclerotic plaque hospitalized in our hospital from May 2009 to April 2013 were enrolled in this study, including 93 patients with carotid atherosclerotic plaque （ob- servation group） and 39 patients without carotid atherosclerotie plaque （control group）. Total cholesterol （TC）, low density lipoprotein cholesterol（LDL-C） , triglyceride （ TG ） , high density lipoprote cholesterol （ HDL-C ） and hyper- sensitive C-reactive protein （hs-CRP） in all patients were detected routinely. Results The observation group had higher TC and higher LDL-C than the control group（P 〈 0.05 and P 〈 0.01, respectively）. However, TG, HDL-C and hs-CRP between two groups had not statistically significant difference （P all 〉 0.05 ）. Conclusion In patients with coronary heart disease, higher TC and higher LDL-C may be related with the formation of carotid plaque, while hs-CRP has not apparently related with the formation of carotid plaque.