cTnI CRP和BNP联合测定对缺血型心力衰竭患者诊断和预后的判断价值

目的探讨心肌肌钙蛋白I（cTnI）、C-反应蛋白（CRP）和B型钠尿肽（BNP）联合检测对缺血型心力衰竭（心衰）诊断和预后的判断价值。方法收集并测定98例缺血型心衰的不同心功能分级患者及95例冠心病无心衰患者血清cTnI、CRP和血浆BNP等指标，并进行比较，随访观察患者近期心脏事件再发生情况。结果心衰患者不同心功能分级组血清cTnI、CRP和血浆BNP水平与无心衰组之间差异均有统计学意义，且心功能越差，其浓度越高（ P均＜0.05）。发生心脏事件组患者出院时血清cTnI、CRP和血浆BNP浓度明显高于未发生心脏事件组（ P均＜0.05）。结论血清cTnI、CRP和血浆BNP在心衰患者中明显升高，三者联合检测对心衰患者临床诊断和预后判断有重要意义。

The diagnostic and prognostic value of the combined measurements of cTnI, CRP and BNP in patients with ischemic heart failure

Objective To explore the diagnostic and prognostic values of combined measurements of cardiac troponin I（cTnI）, C reactive protein（CRP）and B-type natriuretic peptide（BNP）in patients with ischemia heart fail-ure.Methods The serum cTnI, CRP and blood plasma BNP in 98 cases ischemic heart failure patients with different cardiac function classification and 95 coronary heart disease without heart failure patients , and a follow-up observation of the recurrence of recent cardiac events was performed .Results The levels of serum cTnI , CRP and blood plasma BNP between heart failure patients with different cardiac function grading and the control group were compared , and the differences were statistically significant .The worse the heart function was , the higher the concentration was （ P＆lt;0.05）.Serum cTnI, CRP and plasma BNP concentrations at hospital discharge in the cardiac events group were markedly higher than those in the non-cardiac events group （ P＆lt;0.05 ） .Conclusion Serum cTnI , CRP and plasma BNP concentrations in patients with congestive heart failure obviously increase , and the combined measurements of three indexes have important significance in clinical diagnosis and prognostic evaluation for heart failure .