坎地沙坦对原发性高血压患者左心室肥厚的作用

目的研究坎地沙坦对原发性高血压（EH）患者的降压作用和对左室肥厚（LVH）的影响。方法选择52例EH患者，其中有LVH者20例，1：2服坎地沙坦8～16mg／d，为期半年。观察血压、不良反应，治疗前后测血脂、血糖和肝肾功能，并作二维超声心动图检测，采用自身前后对照的实验方法。结果EH患者经坎地沙坦治疗后收缩压、舒张压显著下降（P〈0．01），其中LVH者治疗后左心室舒张末期内径及左室重量均明显下降（P〈0．05），舒张末期左室后壁厚度、室间隔厚度及左室重量指数下降更明显（P〈0．01）。结论坎地沙坦治疗EH安全、有效，并且可逆转LVH。

Effect of Candesartan on Left Ventricular Hypertrophy in Patients with Essential Hypertension

Objective To study the effect of candesartan on left ventricular hypertrophy(LVH) in patients with essential hypertension(EH).Methods The study population consisted of 52 essential hypertensive patients,20 patients with left ventricular hypertrophy.All patients received candesartan 8~16 mg per day for half year.Left ventricular diameter and left ventricular mass index were measured by echoardiography.Results The candesartan significantly decreased systolic blood pressure,diastolic blood pressure in patients with essential hypertension,(P<0.01),For the patients with left ventricular hypertrophy,candesartan reduced both left ventricular end diastolic diameter and left ventricular mass(P<0.05).Meanwhile it were obviously improved for diastolic left ventricular posterior wall thickness,ventricular septum thickness and left ventricular mass index(P<0.01).Conclusion candesartan is effective drug to reverse left ventricular hypertrophy.