宫内生长迟缓孕兔胎盆及胎兔脑组织计量分析

在采用被动吸烟方法建立孕兔胎儿生长迟缓动物模型的基础上，对孕兔胎盘组织及胎兔大脑及小脑皮质颗粒细胞层进行计量分析。结果，吸烟可使胎盆绒毛面织百分比及绒毛毛细血管百分比降低；胎兔大脑及小脑皮质颗粒细胞层的厚度交薄，脑皮质颗粒钿胞层密度亦较无被动吸烟胎兔疏松。提示：整中孕期吸烟，对胎兔大脑及小脑均有影响，而妊娠晚期吸烟时，主要影响其大脑皮层。

The Quantitative and Morphological Analysis of Placenta and Brain in Rabbits with Intrauterine Fetal Growth Retardation

bjecitve To observe the changes of quantitative and morphological structure in placenta and fetal brain of rabbits with intrauterine fetal growth retardation (IUGR) resulted from exposure to cigarette smoking.Methods The pure species of 23 pregnant New Zealand rabbits were used and divided into three groups, (1) group A: 9 rabbits were exposed to cigarette smoking everyday in the whole period of preg-nancy;(2) group B : 7 rabbits were exposed to cigarette smoking everyday in the late half period of pregnancy; (3)group C : no smoking, as control group. The villus area of placenta, the capillary area in villus and the thickness of granulosa layer in fetal brain were studied by histomorphornetric parame-ter.Results It was showed that the placental villus area was decreased significantly in group A than that of the control group. The capillary area in villus of both group A and group B was less than that of the group C. The thickness of granulosa layer in cerebrum and cerebellum of group B is less than that of the control group. Nevertheless, only the thickness of granulosa layer in cerebrum of group B decreased significantly than that of the control group.Conclusions The development of cerebrum in fetal rabbits were influenced significantly by smo-king. The development of cerebellum was influenced by smoking mainly in the early half period of preg-nancy. It means that the most important time for cerebellum developrnent is the early period of pregnan-cy and both the early and late half periOd of pregnancy were important for the cerebrum development.