| 重症肝炎血清氨基酸成份动态观察及与脑脊髓液、脑组织氨基酸对照分析 |
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| 引用本文： | 张捷,王兆荃,金玉珠,李彦卿,张振凡,高红,孙金良,董祥家. 重症肝炎血清氨基酸成份动态观察及与脑脊髓液、脑组织氨基酸对照分析[J]. 中国医科大学学报, 1988, 0(3) |
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| 作者姓名： | 张捷 王兆荃 金玉珠 李彦卿 张振凡 高红 孙金良 董祥家 |
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| 作者单位： | 中国医科大学附属第三医院传染病学教研室(张捷，王兆荃，高红，孙金良)，沈阳市第一传染病医院(金玉珠，李彦卿)，沈阳市第二传染病医院(张振凡)，中国医科大学(董祥家) |
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| 摘 要： | 本文报告了经肝活检确诊的50例重症肝炎患者,于治疗前、后血清氨基酸(AA)的动态观察及与脑脊髓液、脑组织AA对照分析结果表明:重症肝炎急性期芳香族氨基酸(AAA)增加,造成支链氨基酸(BCAA)轻度降低,BCAA/AAA比值下降,经用六合氨基酸治疗后,血AAA明显下降,BCAA/AAA比值上升。同时观察到,经治疗后BCAA/AAA比值上升之病例存活。反之,不上升或下降者死亡。因而AA动态观察有利于预后判定。观察表明:血清AA和脑脊髓液AA含量及BCAA/AAA比值基本上是一致的。脑组织AA与正常对照较高,临床意义尚不清,有待进一步研究。
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| 关 键 词： | 重症肝炎 支链氨基酸 芳香族氨基酸 |
FOLLOW-UP STUDY OF SERUM AMINO ACID COMPONENTS AND COMPARISON WITH THAT IN CEREBRAL SPINAL FLUID AND BRAIN TISSUE IN THE PATIENTS WITH FULMINANT HEPATITIS |
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| Zhang Jie,et al. FOLLOW-UP STUDY OF SERUM AMINO ACID COMPONENTS AND COMPARISON WITH THAT IN CEREBRAL SPINAL FLUID AND BRAIN TISSUE IN THE PATIENTS WITH FULMINANT HEPATITIS[J]. Journal of China Medical University, 1988, 0(3) |
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| Authors: | Zhang Jie et al |
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| Affiliation: | The Third Affiliated Hospital |
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| Abstract: | This paper reportsd 50 cases of fulminant hepatitis diagnosed by liver biopsy. Before and after treatment, the serum amino acie (AA) in these patients was studied and compared with that in cerebral-spinal fluid and brain tissue. The result showed that the aromatic amino acid (AAA) was increased in acute period, the ratio of branc hed chain amino acid (BCAA) to AAA(BCAA/AAA) was decreased. After treatment with 6-AA, the AAA decreased obviously, the ratio of BCAA to AAA increased. The study also showed the patients survived in the group with increased ratio and died in the group with decreased ratio. Therefore, the follow-up study of serum AA could be used to predict the prognosis of the disease.It also showed that AA in both serum and c.s.f and the ratio of BCAA to AAA were essentially the came. The brain content was higher than that in normal control. Its clinical significance was unknown and further investigations were needed. |
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| Keywords: | Fulminant hepatitis Branched chain amino acid Aromatic amino acid |
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