ANP、cGMP和ICVD对血液透析患者干体重评价的意义

目的 观察血浆心钠素(ANP)、环磷酸鸟苷(cGMP)和彩色超声心动测定下腔静脉直径(ICVD)对评价血液透析患者干体重的作用。方法 利用临床经验法和观察指标评价并调整40例血液透析患者的干体重，检测透析前后各观察指标的变化，并与32例正常对照组比较。结果 透析后ANP、cGMP较透析前明显降低，但仍明显高于对照组；临床判断有容量过负荷的患者，降低干体重后，ANP和cGMP明显降低；用ICVD评价为超负荷的患者，其ANP和cGMP明显高于低负荷及正常负荷者。结论 血浆ANP、cGMP的测定可较好反映高容量状态，IVCD对高容量及低容量状态均有良好反映。

The significance of ANP, cGMP and ICVD on evaluating dry body weight of hemodialysis patients

ObjectiveTo observe the effects of ANP, cGMP and the inferior caval vein diameter (ICVD) on evaluating the dry body weight of hemodialysis patients.Methods Assessed and regulated the dry body weight of 40 mainten ance hemodialysis patients with clinical methods and ANP, cGMP and ICVD. Then, c ompared the changes of these indicators before and after hemodialysis and with 3 2 normal controls.Results The levels of plasma ANP and cGMP after hemodialysis wer e significantly lower than before, but all of them were still higher significant ly than the contral. In the overload patients judged by clinical methods, the AN P and cGMP significantly decreased after reducing their dry body weight. The pla sma ANP and cGMP levels in the overload patients evaluated by ICVD were highe r than download and normal patients.Conclusions The plasma levels of ANP and cGMP were better indic ators to assess the overload status in hemodialysis patients. Whereas the ICVD c an be used to evaluate the overload and download status.