A prospective evaluation of phrenic nerve conduction in multifocal motor neuropathy and chronic inflammatory demyelinating polyneuropathy |
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Authors: | Macia Frederic Le Masson Gwendal Rouanet-Larriviere Marie Habonimana Desire Ferrer Xavier Marthan Roger Lagueny Alain |
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Institution: | Department of Neurology, H?pital Haut-Lévèque, Avenue de Magellan, 33604 Pessac, France. |
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Abstract: | The purpose of the study was to evaluate electrophysiologically phrenic nerve involvement in multifocal motor neuropathy (MMN) and chronic inflammatory demyelinating polyneuropathy (CIDP). The response latencies following phrenic nerve stimulation were increased in 11 of 14 (80%) patients in the CIDP group but in only 1 of 14 (8%) patients in the MMN group. The mean diaphragmatic compound muscle action potential (CMAP) was significantly lower in amplitude in the CIDP group compared to the MMN group and to a control group of 8 subjects (P < 0.001). There were no significant differences between the MMN and control groups. Only the reduction in CMAP amplitude correlated with the presence of restrictive lung function. Phrenic nerve conduction measurement should be performed more systematically, especially in CIDP and, when diaphragmatic CMAPs are reduced in amplitude, pulmonary function tests should be performed to look for a restrictive lung syndrome. |
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Keywords: | chronic inflammatory demyelinating polyneuropathy (CIDP) multifocal motor neuropathy phrenic nerve conduction pulmonary function |
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