P27蛋白表达与胃癌发生及临床病理特征的关系

目的]探讨P27蛋白表达在胃癌发生中的意义及与胃癌临床病理特征的关系。方法]用免疫组织化学SP法检测胃腺癌组织58例和非癌胃黏膜上皮组织33例P27蛋白的表达情况，并分析其表达与胃癌发生及临床病理特征的关系。结果]胃癌组P27蛋白的阳性表达率为46．6％（27／58），低于非癌胃黏膜组的81．8％（27／33），（P〈0．01）。P27蛋白表达与胃癌临床病理特征未见明确相关关系。结论]胃癌发生可能与胃粘膜组织P27蛋白表达下调相关。

Associations of P27 expression with carcinogenesis as well as clinical pathological character of gastric carcinoma

Objective]To explore relations of P27 expression to cavcinognensis and clinicalpathological character of gastric carcinoma.Methods] Immunohistochemistry mothed was used to detect P27 expression in 58 samples of gastric carcinomas and 33 samples of non-tumor gastric epithelia,and the associations of expression of P27 with gastric carcinogenesis as well as clinicalpathological character of gastric carcinoma was analyzed.Results] The positive rate of P27 expression was 46.6%(27/58) in gastric carcinoma,and its significantly lower than that(81.8%,27/33) in samples of non-tumor gastric epithelia(P<0.01).P27 expression was not signifi-cantly related to clinicalpathological character of gastric carcinoma.Conclusion] The carcinogenesis may be re-lated to decreasing of P27 expression in sore gostric carcmowas.