Effects of 8-OH-DPAT, a 5-HT1A receptor agonist, and DOI, a 5-HT2A/2C agonist, on monosynaptic transmission in spinalized rats |
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| Authors: | Yutaka Hasegawa Hideki Ono |
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| Institution: | Department of Pharmacy, Branch Hospital, Faculty of Medicine, University of Tokyo, 3-28-6 Mejirodai, Bunkyo-ku, Tokyo 112, Japan |
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| Abstract: | We investigated the effect of the 5-HT1A receptor agonist (±)-8-hydroxy-2-(di-N-propylamino)tetralin (8-OH-DPAT) and the 5-HT2A/2C receptor agonist (±)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) on monosynaptic transmission in spinalized rats. 8-OH-DPAT significantly inhibited the excitation of α-motoneurons evoked by monosynaptic transmission without a direct effect on α-motoneuron excitation. DOI potentiated the excitation of α-motoneurons by both direct stimulation and monosynaptic transmission. These results indicate that activation of 5-HT1A receptors inhibits monosynaptic transmission, whereas activation of 5-HT2A/2C receptors enhances it. |
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| Keywords: | Serotonin 5-HT1A receptor 5-HT2A/2C receptor Spinal cord α -Motoneuron Primary afferent Monosynaptic reflex |
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